Source: PilgrimAfrica, 2016

The RTS,S malaria vaccine candidate is the most advanced in development

globally (Agnandji et al., 2015)

Over the past decade, studies of RTS,S have indicated that it may help protect

young Children and infants in malaria-endemic areas against infection and

clinical disease caused By Plasmodium falciprum, the most deadly species

of the malaria parasite (Gosling and von Seidlein, 2016)

Final results from the Phase 3 efficacy trial of RTS,S, published in The Lancet,

showed that the vaccine candidate helped protect children and infants from

clinical malaria for at least three years after first vaccination (Rts, 2015).



Prevalence of Plasmodium falciparum in Humans, Bulletin of Entomological Research, 87, 445-453).

Centers for Disease Control and Prevention. 1600 Clifton Rd

MS A-06. Atlanta, GA 30329-4027

https://www.cdc.gov/malaris/.../biology/ retrieved 29th september 2016 9.45pm

Enzyme discovery may lead to new ways of fighting malaria, the Francus Crick Institute, 20th


Agnandji, S.T., Fernandes, J.F., Bache, E.B. and Ramharter, M., 2015. Clinical development of RTS, S/AS malaria vaccine: a systematic review of clinical Phase I-III trials. Future microbiology, 10(10), pp.1553-1578.

Gosling, R. and von Seidlein, L., 2016. The Future of the RTS, S/AS01 Malaria Vaccine: An Alternative Development Plan. PLoS Med, 13(4), p.e1001994.

Rts, S.C.T.P., 2015. Efficacy and safety of RTS, S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. The Lancet, 386(9988), pp.31-45.ÒOxborough, R.M., N’Guessan, R., Kitau, J., Tungu, P.K., Malone, D., Mosha, F.W. and Rowland, M.W., 2015. A new class of insecticide for malaria vector control: evaluation of mosquito nets treated singly with indoxacarb (oxadiazine) or with a pyrethroid mixture against Anopheles gambiae and Culex quinquefasciatus. Malaria journal, 14(1), p.1.

Viana, M., Hughes, A., Matthiopoulos, J., Ranson, H. and Ferguson, H.M., 2016. Delayed mortality effects cut the malaria transmission potential of insecticide resistant mosquitoes. Proceedings of the National Academy of Sciences of the United States of America.

Bradley, J., Hergott, D., Garcia, G., Lines, J., Cook, J., Slotman, M.A., Phiri, W.P., Schwabe, C. and Kleinschmidt, I., 2016. A cluster randomized trial comparing deltamethrin and bendiocarb as insecticides for indoor residual spraying to control malaria on Bioko Island, Equatorial Guinea. Malaria Journal, 15(1), p.378.

Protopopoff, N., Wright, A., West, P.A., Tigererwa, R., Mosha, F.W., Kisinza, W., Kleinschmidt, I. and Rowland, M., 2015. Combination of insecticide treated nets and indoor residual spraying in northern Tanzania provides additional reduction in vector population density and malaria transmission rates compared to insecticide treated nets alone: a randomised control trial. PloS one, 10(11), p.e0142671.


Posted by:
Marian Onwude Agbugui
on October 27, 2016


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