Department Of Natural Science Journals


Growth performance and feed utilization of fingerlings of Clarias gariepinus (Teugels) fed processed Pauletia monandra (Kurz) seed meal

MO Agbugui, S.J Oniye, J Auta, FO Abeke

Abstract

The growth performance and feed utilization of fingerlings of Clarias gariepinus fed diets containing a commercial feed and Pauletia monandra seed meal was studied for 56 days. The experimental diets were: diet 1 (37.50% commercial feed +12.50% P. monandra seeds), diet 2 (25.00 commercial feed +25.00 P. monandra seeds), diet 3 (12.50% commercial…
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Plasmid Profile of Uropathogens among Children

  1. C. Ebenebe1, K. M. Emeka-Okafor2, C. N. Akujobi2, C. C. Ezeanya2*, N. R. Agbakoba2 and C. C. Egwuatu2

1Department of Pediatrics, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra

State, Nigeria.

2Department of Medical Microbiology and Parasitology, Faculty of Medicine, Nnamdi Azikiwe

University, Nnewi Campus, Nigeria.

 

ABSTRACT

Aims: The study was carried out in order to determine the plasmid profile, antibiotic susceptibility pattern and the type of antimicrobial resistance (whether it…
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ANTIFUNGAL SUSCEPTIBILITY AND TEST FOR CURE OF CANDIDA SPECIES AMONG VULVOVAGINAL CANDIDIASIS PATIENTS IN A SECONDARY CARE HOSPITAL, NIGERIA

Ejike, C. E1; Agbakoba, N. R2; Ezeanya, C. C3; Emele, F. E4; Oguejiofor, C. B5 & Dirisu, J.2

1Department of Medical Microbiology, Chukwuemeka Odimegwu Ojukwu University, Awka Campus, Nigeria; 2Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus. Nigeria; 3Department of Medical Microbiology, Edo University Iyamho, Edo State, Nigeria; 4Department of Medical Microbiology and Parasitology, Nnamdi Azikiwe University, Nnewi Campus,…
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Ohanmu,E. O., Bako,S. P. and Adelanwa,M. A.

The effect of crude oil spillage on the growth performance of Capsicum frutescens L. (chilli pepper)was assessed in a polythene bag treated with 0 mL (control), MI (75% unpolluted + 25% crude oil polluted soil) and HI (50% unpolluted soil + 50% crude oil polluted soil) respectively. The various concentrations were arranged in a complete randomized block design during the rainy and dry season respectively. The plant height, leaf number, leaf area and…
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ABSTRACT

 

The effect of crude oil on growth and survival of Capsicum annuum was investigated in Ahmadu Bello University, Zaria. Planting was done in polythene bags measuring (60 x 25x 15cm) and each bag was filled with 15kg of top soil (0-15m depth) collected from Ologbo flow station, Benin City. Two polythene bags per crude oil concentration were replicated thrice in a randomized block design which made a total of 18 bags. Treatment of the soil was…
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MacDonald Idu 1*, Goddidit Igbafe 1, Joseph Erhabor 1

  1. Abstract

    Materials and methods: Routine methods were used in this study.

    Conclusion: J. tanjorensis contains important elements which if used in recommended doses could be of immense benefits to man.

    Keyword: Anti-anaemic, Acute toxicity, proximate analysis, Jatropha tanjorensis, Rabbits.


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The efficient use of plant genetic resources requires the careful collection of germplasm, its conservation, evaluation, documentation and exchange. Over the last few decades, plant tissue culture has been used to propagate hundreds of plant species. The use of this technique has been particularly important for conservation and multiplication of plants that produce seeds, propagated vegetatively, recalcitrant or have unpredictable seed germination. In vitro collection is a natural outgrowth of this work. Tissue culture being a basic component of plant…
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ABSTRACT

 

On-farm research is a set of procedures for adaptive research aimed at developing recommendations for representative groups of farmers. These groups of farmers’ plots are used as the research site, thereby allowing for appropriate site specific technology, valid results and faster adoption. The move towards on-farm research means that researchers, such as plant breeders and agronomists, who have been trained in techniques of on-station research, are now under pressure to move on-farm. As a result of variations between…
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Corchorus (L) is an important vegetable, grown mainly for its leaves. It contributes to the dietary requirements of the local populace as well as local economy. Five accessions, three labeled NHCO3, NHCO25 and NHCO26 obtained from the Plant Genetic Resources Unit of Nigerian Institute of Horticulture (NIHORT), Ibadan and two BN/OD/01 and ON/OD/02 obtained from home gardens were evaluated for their proximate: ash, moisture, carbohydrate, protein, lipid and fibre contents. Result showed that all biochemical parameters evaluated vary significantly (P0.05)…
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ABSTRACT:

The isolation of hydrocarbon-degrading bacteria in topsoil and subsoil samples of selected mechanic workshops located in the Benin metropolis was carried out. The highest and lowest bacterial counts in topsoil samples were found out to be 2.94 x 106 CFU/g and 2.39 x 106 CFU/g in CENTRAL road and OGBELAKA road automobile workshops respectively.   The highest and lowest bacterial counts in subsoil samples were found out to be 1.14 x 106 CFU/g and 1.09 x 106 CFU/g in OGBELAKA…
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Abstract

The study investigated the exogenous application of Naphthalene acetic acid (NAA) on the vegetative traits of two varieties of pepper (Capsicum annuum L. and Capsicum frutescens L.) the treatment were 0, 1, 5, 10 and 20 ppm NAA. NAA at 1ppm concentration increased plant height, leaf area and number of leaves in both varieties. Shoot height of 23.17 ± 1.45 cm was recorded in C. annuum at 1 ppm treatment as against 18.90 ± 3.12…
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 ABSTRACT

Five accessions labeled NHCO3, NHCO25, NHCO26, BN/OD/O1 and ON/OD/02 of Corchorus L. (Malvaeae) obtained from National Horticultural Research Institute (NIHORT), Ibadan, Nigeria and home gardens in Benin City and Owo were evaluated in the University of Benin, Benin City. Primary data were obtained based on eleven qualitative and nine quantitative agro-morphological characters. These characters include: growth features of stem and leaves, plant height days to 50% germination, days to 50% flowering, days to 50% fruiting,…
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413  samples  of  Pomad asys jubelini  were  obtained  from  the  New  Calabar-Bonny  River  and  examined  over a period of twenty four months. The length ranged from 8.50cm -  47.60 and the weight from 17.00g -   2320g.  Females were longer and heavier than males. There was a strong and positive relationship between fish length and
weight  (r) = 0.91 for males and 0.99 females, and b value (b<3) indicating a negative allometric growth.The monthly condition factor (K) ranged…
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Anurans as Inter mediate and Paratenic Hosts of Helminth Infections in the Rainforest and Derived Savanna Biotopes of Southern Nigeria

Abigail A. Imasuen, Habibat J. Ozemoka, and Martins S. O. Aisien

Abstract

Anurans from the rainforest (Okomu National Park) and derived savanna (Agbede) locations in Nigeria were investigated for their role either as inter mediate or paratenic hosts of helminth infections. A total of 269 anuran specimens (157 from the Okomu National Park and 112 from Agbede) were examined. Metacercariae…
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Parasitic infections of the African dwarf crocodile (Osteolaemus tetraspis) and the ornate Nile monitor (Varanus ornatus) from Nigeria

Elisha E. Enabulele, Habibat J. Ozemoka, Agnes O. Awharitoma and Martins S.O. Aisien*

Abstract

The parasitic infections of market derived Osteolaemus tetraspis from the rainforest and Varanus ornatus from locations in the savanna-mosaic and the rainforest of southern Nigeria were investigated. Parasites recovered from O. tetraspis included members of the Pentastomida, Trematoda and Nematoda. An undescribed pentastomid belonging to the family Sebekidae…
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Falade, M.O., Opene, A.J. and Benson, O., 2016. DNA barcoding of Clarias gariepinus, Coptodon zillii and Sarotherodon melanotheron from Southwestern Nigeria. F1000Research, 5.

 

Abstract

DNA barcoding has been adopted as a gold standard rapid, precise and unifying identification system for animal species and provides a database of genetic sequences that can be used as a tool for universal species identification. In this study, we employed mitochondrial genes 16S rRNA (16S) and cytochrome oxidase subunit I (COI) for…
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Oloyede, O.O., Otarigho, B. and Morenikeji, O., 2017. Diversity, distribution and abundance of freshwater snails in Eleyele dam, Ibadan, south-west Nigeria. Zoology and Ecology, 27(1), pp.35-43.

 

Abstract

Freshwater molluscs help in the assessment of the ecological status of water bodies and also play significant roles in the public and veterinary health. Hence, scientific studies pertaining to their diversity, distribution and abundance become essential. In Eleyele dam, freshwater snails were sampled and physicochemical parameters of the water body were analysed…
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Falade, M.O. and Otarigho, B., 2016. Comparative structural and functional features of folate salvage transporters in Plasmodium falciparum and humans. Journal of Biotech Research, 7, p.20.

 

Abstract

Folic acids are essential cofactors for synthesis of DNA, RNA, membrane lipids, methionine metabolism and neurotransmitter synthesis. P. falciparum is capable of synthesizing folate de novo or obtaining it through salvage, whereas humans can only obtain folate from their diet, making the folate pathway products important targets for chemotherapy. Although…
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Oloyede, O.O., Otarigho, B. and Morenikeji, O., 2016. Conditions of Eleyele dam in Ibadan Nigeria inhabited by Melanoides tuberculata. Sustainability of Water Quality and Ecology, 7, pp.22-31.

 

Abstract

Melanoides tuberculata is now been monitored worldwide because of its fast growing distribution and its economic importance. M. tuberculata, a freshwater mollusc that is an invasive species of freshwater snail, serves as vector transmitting several diseases causing parasites, was found inhabiting Eleyele dam in Ibadan, Nigeria. The prevailing environmental…
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Onile, O.S., Otarigho, B. and Anumudu, C.I., 2014. Understanding the Phylogenetics and Evolution of Genus Schistosoma-Africa and Asia Stand Point. Annual Research & Review in Biology, 4(10), p.1703.

 

Abstracts

The evolutionary spread of schistosomes infection was reportedly prominent more in Africa and Asia continents. This study therefore examined the evolutionary trend of this parasite while limiting the investigation to Schistosoma species peculiar to this region of the world. The evolutionary history of this species group was inferred using DNA…
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Falade, M. and Otarigho, B., 2017. Genome-wide characterization of folate transporter proteins of eukaryotic pathogens. F1000Research, 6.

 

Abstracts

Medically important pathogens are responsible for the death of millions every year. For many of these pathogens, there are limited options for therapy and resistance to commonly used drugs is fast emerging. The availability of genome sequences of many eukaryotic protozoa is providing important data for understanding parasite biology and identifying new drug and vaccine targets. The folate synthesis and salvage…
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Otarigho, B. and Morenikeji, O.A (2013) Molluscicidal Effects of Aqueous and Ethanolic Extracts of Lemongrass (Cymbopogon Citratus) Leaf against the Different Developmental Stages of Biomphalaria pfeifferi NY Sci J 2012;5(8):70-77]. (ISSN: 1554-0200).

 

Abstract

The molluscicidal activities of aqueous and ethanolic extracts of Cymbopogon citratus leaf against adult, juveniles and egg-masses of Biomphalaria pfeifferi were investigated. Ten adults each of Biomphalaria pfeifferi were exposed to a serial dilution of 40, 80, 160, 240, 320, 400, and 480ppm distilled…
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Benson, O., 2012. Efficacy of Chromolaena odorata leaf extracts on Biomphalaria pfeifferi eggs in control of Schistosomiasis. Zoology and Ecology, 22(3-4), pp.236-239.

 

Abstract

Schistosomiasis is still a problem in many parts of the world, with 85% infection in Africa. There is a need to control the snail, which is essential to complete the transmission circle. The molluscicidal activities of aqueous and ethanolic leaf extracts of Chromolaena odorata against eggs of Biomphalaria pfeifferi were investigated. Thirty viable eggs…
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Mofolusho O. Falade and Benson Otarigho, 2015. Shell Morphology of Three Medical Important Tropical Freshwater Pulmonate Snails from Five Sites in South-Western Nigeria. International Journal of Zoological Research, 11: 140-150.

 

Abstracts

Biomphalaria pfeifferi, Bulinus globosus and Lymnaea natalensis act as obligatory vectors of schistosomiasis and fascioliasis in Sub-Saharan Africa. Although, they are known to be widely distributed throughout Nigeria, there is the need for precise species identification to help vector control initiatives. Snail shell morphometry has…
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Falade, M.O. and Otarigho, B., 2013. Survival potential, fecundity and fertility of Biomphalaria pfeifferi (Krauss, 1848) during acclimatization in the laboratory. Zoology and Ecology, 23(2), pp.157-161.

 

Abstract

Survival potential, fecundity and fertility of Biomphalaria pfeifferi were investigated during the process of acclimatization in the laboratory. Thirty adult snails (average size 5?×?13?mm) were used in Experiment A (control; laboratory-bred snails) and B (acclimatizing snails from the wild). Both experiments aimed at monitoring survival and reproductive potential of snails…
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Otarigho, B. and Morenikeji, O.A., 2013. Efficacy of aqueous and ethanolic extracts of leaves of Chromolaena odorata as molluscicide against different developmental stages of Biomphalaria pfeifferi. African Journal of Biotechnology, 12(4).

 

Abstract

The molluscicidal activities of aqueous and ethanolic extracts of leaves of Chromolaena odorata were investigated on adult, one week old juveniles and 3 to 4 days old egg-masses of Biomphalaria pfeifferi. Ten adults each were exposed to a serial dilution of 40, 80, 160, 240,…
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Ajayi OO, Charles-Davies MA, Arinola OG (2012). Progesterone, selected heavy metals and micronutrients in pregnant Nigerian women with a history of recurrent spontaneous abortion. African Health Sciences 12(2):152-158.

Abstract

Background

Environmental and endocrine factors have been implicated in the aetiology of recurrent abortion, with poorly understood roles. Luteal phase insufficiency marked with insufficient progesterone secretion has been reported.

Objective

To define the involvement of progesterone, trace metals, and Vitamin E in pregnant women with history of recurrent spontaneous abortion.


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Olulope O. Ajayi, Mabel A. Charles-Davies, John I. Anetor, Adeyinka F. Ademola (2016). Sex hormones, oestrogen receptor, progesterone receptor and human epithelial receptor 2 expressions in pre and postmenopausal sub-Saharan African women with breast cancer. Journal of Cancer and Tumour International 3(4):1-11

Abstract

Aim: This study was carried out to determine the serum levels of sex hormones and gonadotropins as well as the expression of oestrogen receptor (ER), progesterone receptor (PR) and human epithelial receptor 2 (HER 2) in pre…
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OO Ajayi, MA Charles-Davies, JI Anetor, AF Ademola (2017).  Endocrine disruptors-arsenic, cadmium and lead in pre and postmenopausal black women with breast cancer. African Journal of Medicine and Medical Sciences 46

Abstract

Background: The involvement of toxic metals in adiposity has been suggested to be contributory to the high incidence of breast cancer, particularly in sub-Saharan Africa. This study is aimed at evaluating serum arsenic, cadmium and lead in relation to adiposity and blood pressure in Nigerian women with breast…
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OO Ajayi, MA Charles-Davies, JI Anetor, AF Ademola (2017). Thyroid hormones and obesity in Nigerian women with breast cancer. African Journal of Medicine and Medical Sciences (manuscript accepted; 12th May, 2017).

Abstract

Background: Africans have breast cancer expressions different from Caucasians. Interactions between oestradiol (E2), adiposity and thyroid hormones in breast cancer development have been reported but controversial. The study was designed to investigate the relationships among thyroid hormones, E2 and adiposity in Nigerian pre and postmenopausal women with breast…
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A novel bioflocculant-producing bacteria was isolated from sediment samples of

on the bioflocculant production was investigated. Analysis of the partial nucleotide

the sequence was deposited in GenBank as Cobetiasp. OAUIFE (accession number

optimal with an inoculum size of 2% (v/v), initial pH of 6.0, Mn2+ as the metal ion, and

bioflocculant production, resulting in flocculating activity of above 90%. This crude

heating at 100 °C for 25…
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Ugbenyen AM, Mkwetshana N and Okoh AI (2012). Characterization of an extracellular bioflocculant produced by Cobetia sp. OAUIFE isolated from  marinesediment. Journal of Pure and Applied Microbiology. 6(4): 1591- 1598.

Abstract:The characteristics of a bioflocculant produced by Cobetiasp. OAUIFE isolated

from sediment samples of Algoa Bay, South Africa was investigated. The acidic extracellular

polysaccharidebioflocculant optimally flocculated kaolin suspension at a dose of 0.4

mg/ml, neutral pH of 7, and Ca2+ as a coagulant aid. The bioflocculant is thermostable,

with a high…
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Ugbenyen AM and Okoh AI. (2013) Flocculating Properties of a Bioflocculant Produced by Bacillus sp. Isolated from a Marine Environment in South Africa. Chemical and Biochemical Engineering- Quarterly. 27(4): 511-518.

Abstract:We assessed the biotloeeulant production by a bacteria isolated from a marine environment

in South Africa. The 16S rDNA nucleotide sequence analyses revealed the bacteria

to have a 99 % similarity to Bacillus sp. A-5A and the sequence was deposited in

theGenbank as Bacillus sp. MAYA (accession number JF799093). Biofloeculant production


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The characteristics of a bioflocculant produced by a consortium of 2 bacteria belonging to the genera Cobetiaand Bacillus was investigated. The extracellular bioflocculant was composed of 66% uronic acid and 31% protein and showed an optimum flocculation (90% flocculating activity) of kaolin suspension at a dosage of 0.8 mg/m?, pH of 8, and with Ca2+ as a coagulant aid. The bioflocculant is thermally stable, with a high residual flocculating activity of 86.7%, 89.3% and 87% after heating at…
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Ugbenyen, A.M, Cosa, S., Mabinya, L.V., Okoh A.I. (2014). Bioflocculant production by Bacillus sp. Gilbert isolated from a marine environment in South Africa. Applied Biochemistry andMicrobiology. 50(1):49-54 (Springer).

Abstract: In our previous study we reported on the bioflocculant production by a Bacillus species isolated from sediment samples of Algoa Bay in the Eastern Cape Province of South Africa. In the current study we carried out further evaluation on the effect of different culture conditions on the bioflocculant production, as well…
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Ugbenyen Anthony Moses, Vine Niall, Simonis Jean Jacques, BassonAlbertusKotzeand Okoh Anthony Ifeanyi. (2015). Characterisation of a bioflocculant produced from the consortium of three marine bacteria of the genera Cobetia and Bacillus and its application for wastewater treatment. Journal of Water, Sanitation and Hygiene for Development. 5(1): 81-88.          

 

Abstract: In this study, we purified and characterized bioflocculant from a mixed culture of three marine

bacteria (Cobetia sp. OAUIFE, Bacillus sp. MAYA, and Bacillus sp. Gilbert with accession number

JF799092, JF799093,…
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Ugbenyen Anthony Moses, Vine Niall, Simonis Jean Jacques, BassonAlbertusKotzeand Okoh Anthony Ifeanyi.(2014).Extraction,characterization and application of a Bioflocculant produced from a mixedculture of two bacteria strains isolated from Algoa Bay, South Africa.StudiaUniversitatis “VasileGoldis” 24(1): 11-17.

Abstract:

 Two bioflocculant-producing marine bacteria isolated from the sediment samples of Algoa Bay in the Eastern Cape Province of South Africa identified as Cobetiasp. OAUIFE and Bacillus sp. Gilbert (accession number JF799092, and HQ537128 respectively) were used in a mixed culture to produce a bioflocculant of…
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Cosa S, Ugbenyen AM, Mabinya L, Karl Rumbold and Okoh AI.(2013) Characterization andflocculationefficiency of a bioflocculant produced by a marine bacteria belonging to theHalobacillus genus. EnvironmentalTechnology. 34(18): 2671-2679 (Taylor & Francis).

Abstract: We reported earlier on the bioflocculant production potential of Halobacillussp. Mvuyo, a marine bacteria isolated from Algoa Bay sediment samples. In this paper we report on the detailed characterization of the purified bioflocculant composed of polysaccharide and protein. The optimum dose of the purified bioflocculant for the clarification…
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Cosa S., Ugbenyen MA., Mabinya V.L., Rumbold K., Olaniran OA., Aghdasi F. and Okoh I.A.(2013). Oceanobacillus sp. Pinky, a marine bacteria isolated from Algoa Bay sediment produces a thermostable glycoprotein flocculant African Journal of Biotechnology. 12(26): 4135- 4146.

 

 

Abstract:

In this study, we report on the bioflocculant production potential of an Oceanobacillussp. isolated from the marine sediments of Algoa Bay. The bacteria produced an extracellular bioflocculant optimally in the presence of sodium carbonate as source of carbon with…
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SekelwaCosa, Moses A Ugbenyen, and Anthony I Okoh(2013).Characterization ofa polysaccharide bioflocculant produced by Virgibacillusspecie isolated from Algoa Bay. African Journal of Microbiologica Research. 7(23): 2925-2938.

Abstract:

We evaluated the bioflocculant production by Virgibacillusspecie isolated from a marine environment in the Eastern Cape Province of South Africa. Culture conditions for optimal production of the bioflocculant included: glucose as sole carbon source (flocculating activity 91.8%); complex nitrogen source (urea + yeast extract + (NH4)2SO4); inoculum size of 2% (v/v); initial pH 10;…
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Arinola OG and Rahamon S.K. Biochemical Nutritional Parameters in Breast-milk and Plasma of HIV Infected Lactating Nigerian Mothers on Anti-Retroviral Therapy. Sierra Leone Journal of Biomedical Research 2011; 3 (1): 4-7.

ABSTRACT

Undernourishment in HIV infected individuals exacerbates immunosuppression, acceleration of HIV replication and CD4 + T cell depletion.  The production of human milk (lactogenesis) is dependent on factors in the blood therefore deranged blood parameters in HIV patients are expected to reflect in the components of breast milk. Study…
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Olaniyi JA, Anifowose A, Awosika EO, Akinloye O, Rahamon SK, and Arinola OG. Antioxidant Levels of Acute Leukaemia Patients in Nigeria. Sierra Leone Journal of Biomedical Research 2011; 3(3): 133-137.

 

ABSTRACT

The incorporation of nutritional screening and comprehensive assessments of oxidative stress is increasingly recognised as imperative in the development of standards for quality care in oncology. This study evaluated the levels of nitric oxide (NO), some essential trace metals (Zn, Cu, Fe, and Se), superoxide dismutase (SOD) activity…
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Akinloye O, Adegbenro M, Olaniyi JA, Rahamon SK, Anifowose AI, Awosika EO and Arinola OG. Plasma Interferon-? and IL-4, Immunoglobulin Classes and Nitric Oxide in Nigerians with Acute Leukaemia. Sierra Leone Journal of Biomedical Research 2011; 3(3): 138-143.

 

ABSTRACT

Acute leukaemia  are usually rapidly progressive with death often occurring in a few weeks to a few months in untreated patients as a result of abnormal hematopoietic function as well as impaired immune response. The risk of relapse which remains…
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Edem VF, Kosoko AM, Akinyoola SB, Owoeye O, Arinola OG, Rahamon SK. Plasma antioxidant enzymes, lipid peroxidation and hydrogen peroxide in wistar rats exposed to dichlorvos insecticide. Archives of Applied Science Research 2012; 4: 1778-1781.

 

ABSTRACT

Dichlorvos is an organophosphate insecticide used indiscriminately in Nigeria in various insecticide formulations due to its cheap production, accessibility, efficacy and affordability. Reactive oxygen species formation has been implicated in the mechanism of dichlorvos toxicity.  Reports on antioxidant-prooxidant status in human users of…
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Background: Metabolic Syndrome (MS) increases the risk of developing type-2 diabetes (DM2) and cardiovascular diseases (CVD) and it is thought to be prevalent in Nigeria. This study aims at determining the prevalence of MS and its component risk factors among apparently healthy traders in a local market in Ibadan, Nigeria.

Results: 301 (56.4%) of traders studied were overweight (176, 33.0%) or obese (125, 23.4%) while 17 (3.4%) and 125 (40.4%) were underweight and normal weight respectively.…
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Edem VF, Akinyoola SB, Olaniyi JA, Rahamon SK, Owoeye O, Arinola OG. Haematological Parameters of Wister Rats Exposed to 2, 2 Dichlorovinyl Dimethyl Phosphate Chemical. Asian J Exp Biol Sci 2012; 3(4): 838-841.

 

 

ABSTRACT

Haematological indices were determined in 21 male Wistar rats that were 
exposed to 2, 2 dichlorovinyl dimethyl phosphate (DDVP) by inhalation. The animals were 
divided into seven groups, viz; unexposed control group and six groups exposed to DDVP 
for 1-6weeks in…
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Olayanju OA, Rahamon SK, Arinola OG. Salivary immunoglobulin classes in Nigerian cigarette smokers: indication for increased risk of oral diseases. Dent Res Journal 2012; 9 (5): 531-534.

 

 

ABSTRACT

Background: Cigarette smoking is a worldwide social epidemic and it is one of the main causes of preventable death and disability. Gingivitis, periodontitis, pocket depth, attachment loss, alveolar bone loss, and tooth loss are some of oral pathologies commonly found in cigarette smokers. The aim of this study was to…
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Arinola OG, Yaqub SA, Rahamon SK. Reduced serum IgE level in Nigerian children with helminthiasis compared with protozoan infection: Implication on hygiene hypothesis. Annals of Biological Research 2012; 3 (12): 5754-5757.

 

 

ABSTRACT

Parasitosis is a major health problem in Nigeria with 50% prevalence among urban dwellers and 68% prevalence among rural population. Serum IgE differs with allergy and chronicity of infection but information on IgE levels in humans with different classes of parasites is scarce. Stool and blood…
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Owoeye O, Edem VF, Akinyoola BS, Rahamon SK, Akang EE, Arinola OG. Histological changes in liver and lungs of rats exposed to dichlorvos before and after vitamin supplementation. European Journal of Anatomy 2012; 16(3): 190-198.

 

ABSTRACT

This study evaluated the effect of vitamins with antioxidant activity on the effect of Dichlorvos (2, 2-dichlorovinyl dimethyl phosphate), an organophosphorus compound used in pest control on mammalian organs. Literature is scanty on the histopathological effects of inhalationally…
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Rahamon SK and Arinola OG. Immunoglobulin Classes and Acute Phase Proteins in the Breast Milk and Plasma of Nigerian Lactating HIV-infected Mothers. Eur J Gen Med. 2012; 9 (4): 241-246.

 

ABSTRACT

Relationship between infections and human breast milk still requires more research especially, in developing countries. This study aims to evaluate the effects of HIV infection on immunologic factors in the breast milk and plasma of HIV infected lactating mothers. Plasma and breast milk concentrations of immunoglobulins G, A,…
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Rahamon SK, Akiibinu MO, Arinola OG. Essential Trace metals and Total Antioxidant Potential in the breast milk and plasma of Nigerian HIV-infected lactating mothers. Journal of Research in Medical Sciences 2013; 18 (1): 27-30.

 

 

ABSTRACT

Background: The effect of Human Immunodeficiency Virus (HIV) on the immune system is well documented however; its impact on the nutritional and immunological qualities of the breast milk is scarce.

Aim: Levels of some essential trace metals, albumin and antioxidant status in the plasma…
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Objective: This study assessed the diagnostic performance and prognostic properties of C-reactive protein (CRP), copeptin and cortisol in individuals with sickle cell anaemia (SCA).

Methods: Sixty consecutive SCA subjects (18–40 years) comprising 30 subjects in the steady state and 30 subjects in vasoocclusive crisis (VOC) were recruited into this study. Thirty (30) apparently healthy individuals with HbAA genotype served as controls. ELISA was used for the determination of serum levels of copeptin, CRP and cortisol. Data…
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Ajani FO, Adelakun A, Ogunleye TD, Disu E, Olaniyi J, Rahamon SK, Arinola OG. Raised IgE level in Nigerian Sickle Cell Disease Children: Implication for severity of allergic reactions. J Appl Hematol 2013; 4 (4):149-152.

 

 

ABSTRACT

Background: Susceptibility of sickle cell disease subjects to various infectious agents is on the increase, but information relating SCD to allergic condition is scarce. Hence, assessment of immunoglobulin status in SCD children may provide useful information to improve management of SCD children.


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Akinlade KS, Atere AD, Rahamon SK, Olaniyi JA. Serum levels of copeptin, C-reactive protein and cortisol in different severity groups of sickle cell anaemia. Nigerian Journal of Physiological Sciences 2013; 28 (2):159-164.

 

ABSTRACT

It is well known that individuals with SCA undergo constant physiological stress even, in steady state. However, there is little information on the relationship between the severity of sickle cell anaemia (SCA) and serum levels of biomarkers of stress. This study therefore determined the serum levels…
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Charles-Davies MA, Fasanmade AA, Olaniyi JA, Oyewole OE, Owolabi MO, Adebusuyi JR, Hassan OO, Ajobo BM, Ebesunun MO, Adigun K, Akinlade KS, Fabian UA, Popoola OO, Rahamon SK. Metabolic Alterations in Different Stages of Hypertension in an Apparently Healthy Nigerian Population. International Journal of Hypertension 2013; 2013: 351357

 

 

ABSTRACT

Metabolic syndrome (MS) amplifies hypertension (HTN) associated with increased risk of cardiovascular disease (CVD). MS components and other CVD risk measures were investigated in different stages of hypertension. 534…
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Rahamon SK, Charles-Davies MA, Akinlade KS, Olaniyi JA, Fasanmade AA, Oyewole AA, Owolabi MO, Adebusuyi JR, Hassan OO, Ajobo BM, Ebesunun MO, Adigun K, Fabian UA, Popoola OO, Okunbolade W, Arinola OG, Agbedana EO. Impact of dietary intervention on selected biochemical indices of inflammation and oxidative stress in Nigerians with metabolic syndrome. European Journal of Nutrition & Food Safety 2014; 4 (2): 137-149.

 

 

ABSTRACT

Aim: This study assessed the impact of dietary modification on cardiometabolic, inflammatory and oxidative…
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Charles-Davies MA, Fasanmade AA, Olaniyi JA, Oyewole OE, Owolabi MO, Adebusuyi JR, Hassan OO, Ajobo MT, Ebesunun MO, Adigun K, Akinlade KS, Fabian UA, Popoola OO, Rahamon SK, Okunbolade W, Ogunlakin MA, Arinola OG and Agbedana EO. Prevalent Components of Metabolic Syndrome and Their Correlates in Apparently Healthy Individuals in Sub-Saharan Africa. International Journal of Tropical Disease and Health 2014; 4(7):740-752.

 

 

ABSTRACT

Aim: To assess the prevalent components of metabolic syndrome (MSC) and their related determinants of…
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Yaqub SA, Rahamon SK, Arinola OG. Haematological and immunological indices in Nigerian farm workers occupationally exposed to organophosphate pesticides. Eur J Gen Med 2014; 11 (2): 109 – 114.

 

 ABSTRACT

Experimental studies have shown numerous health disorders associated with occupational exposure to organophosphate pesticides but evidence of impaired immune functions by pesticides in humans is scarce. This study determined complete blood count (CBC), serum immunoglobulin classes (IgE, IgA, IgM, IgG), acetylcholinesterase (AChE) activity and skin sensitivity prick test…
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Background: Abnormal lipid homeostasis has been reported in sickle cell anaemia (SCA) as well as in other haematological disorders. However, there is little information on the lipid profile of SCA subjects in vaso-occlusive crisis (VOC). This study determined the lipid profile of adult SCA subjects in VOC and in steady state (SSCA).

Materials and Methods: Fifty-eight (58) adults with HbSS (30 in steady state and 28 in vaso-occlusive crisis) and 24 age-matched healthy individuals with HbAA…
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Yaqub SA, Rahamon SK, Kosoko AM, Arinola OG. Oxidative stress indices in Nigerian pesticide applicators and farmers occupationally exposed to organophosphate pesticides. Int J App Basic Med Res 2014; 4(S1):37-40.

 

 

ABSTRACT

Background: Reports have clearly indicated the role of oxidative stress in the pathogenesis of organophosphate pesticides (Op) toxicity. However, there is dearth of information on which group of the farm workers is more at risk of Op-induced oxidative stress.

Aim: This study determined serum levels of malondialdehyde…
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Yaqub SA, Rahamon SK, Arinola OG. Hepatic and Renal functions in Applicators and Farmers Exposed to Organophosphate Pesticides in Southwest, Nigeria. Archives of Basic and Applied Medicine 2014; 2: 83-86.

 

 

ABSTRACT

Prolonged exposure to organophosphate pesticides (Op) has been associated with various diseases. There is little information on which group of exposed farm workers that is more affected. This study therefore evaluated indices of hepatic and renal function in pesticide applicators and farmers exposed to organophosphate pesticides. Thirty…
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Akinlade KS, Atere AD, Rahamon SK, Olaniyi JA, Ogundeji SP. Vitamin D, bilirubin and urinary albumin-creatinine ratio in adults with sickle cell anaemia. Archives of Basic and Applied Medicine 2014; 2: 77 -82.

 

 

ABSTRACT

The interaction between vitamin D deficiency (VDD) and dysfunction of both the kidney and liver is still poorly understood in different health states of SCA. This study determined serum levels of vitamin D and indices of liver and renal function in adult sickle cell…
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Akinlade KS, Fagbomedo FO, Rahamon SK, Makanjuola VA, Ampitan AB. Serum copeptin and its diagnostic performance in schizophrenia. Afr J Med Med Sci 2014; 43: 259-264

 

 

 

ABSTRACT

BACKGROUND:

Inappropriate arginine vasopressin (AVP) secretion has been reported in schizophrenic patients. However, there is lack of information on serum level of copeptin and its diagnostic performance in schizophrenia. This study therefore, evaluated serum copeptin and its diagnostic performance in schizophrenic patients.

METHODS:

Sixty subjects (30.02 ± 7.17 years) with schizophrenia (19 drug naïve [DNS] and 41 schizophrenics on treatment [SOT]) and 30 healthy individuals (33.62…
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Yaqub SA, Rahamon SK, Edem VF, Arinola OG. Elevated Blood Pressure in Nigerian Farm workers occupationally exposed to Organophosphate Pesticides. Afr J Med med Sci 2014; 43(Suppl):187-192.

 

ABSTRACT


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Akinlade KS, Azeez AA, Adeleye JO, Rahamon SK. Serum copeptin as severity and prognostic marker in hyperglycemic emergencies. Annals of Biological Research 2015; 6(6): 13-20.

 

 

ABSTRACT

Despite the high mortality and morbidity associated with hyperglycemic emergencies (HEs), reliable biological markers that could predict the severity and prognosis are largely unavailable. This study therefore, assessed the performance of copeptin in predicting the severity and prognosis of HEs. Sixty patients with HEs [27 with diabetes ketoacidosis (DKA) and 33 with…
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Ogunleye TD, Disu EA, Adelakun AA, Ajani OF, Rahamon SK, Arinola OG. Acute-phase reactants, essential trace elements and some hematological parameters in Nigerian children with steady state sickle cell disorder. Journal of Medicine in the Tropics 2015; 17(2): 56-59.

 

 

ABSTRACT

Background: Sickle cell disease (SCD) is an inherited chronic hematological disorder, with inflammatory responses arising from different pathways. Information is scarce about the levels of acute-phase reactants and essentials trace elements in HbSS Nigerian children. Understanding of these…
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Uwaetteh AE, Akinlade KS, Rahamon SK. Effect of metformin use on thyroid function in euthyroid type 2 diabetes mellitus patients. Archives of Applied Science Research 2015; 7(6): 44-47.

 

 

ABSTRACT

Studies have shown that there is an association between type 2 diabetes mellitus and thyroid dysfunction although, the mechanism is poorly understood. This study assessed the thyroid function in euthyroid T2DM patients on metformin and its possible relationship with duration of metformin use. Thirty-five euthyroid T2DM patients who have…
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Background: A number of biochemical predictors of preeclampsia have been reported, but little is known about their possible relationship with maternal and fetal outcomes. This study determined serum copeptin in pregnant women with preeclampsia and assessed its relationship with pregnancy outcomes.

Results: Copeptin was significantly elevated in preeclampsia subjects compared with controls and in SP compared with MP. Assessing the diagnostic property of copeptin for preeclampsia, the area under the curve for copeptin was 0.99. Nine…
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Usunobun Usunomena, Egharevba M. Ewaen and Ehiosun Kevin (2017). Comparative in vitro antioxidant activity of ethanol extracts of Vernonia amygdalina and Annona muricata leaves. Nigerian Journal of Pharmaceutical and Applied Science Research, 6(1):37-42.

Abstract

In this work, in vitro antioxidant activities of ethanol extracts of Vernonia amygdalina (VAE) and Annona muricata (AME) leaves were comparatively evaluated using reducing power, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, hydrogen peroxide (H2O2) and superoxide anion radical scavenging assays as well as their inhibition concentration (IC50). The results…
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Folasade M. Olajuyigbe and Kevin I. Ehiosun (2016). Assessment of crude oil degradation efficiency of newly isolated actinobacteria reveals untapped bioremediation potentials. Bioremediation Journal, 20(2):133-143.

 

Abstract

Bioremediation is gaining favourable attention as a more economical and environmentally friendly technique for the remediation of crude oil hydrocarbons. This makes the search for crude oil– degrading microbes very crucial. In this study, the isolation and identification of actinobacteria in soil samples from a selected crude oil spill site were carried out.…
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Folasade M. Olajuyigbe, Kevin I. Ehiosun and Kikelomo F. Jaiyesimi (2015). Preliminary Study towards Enhanced Crude Oil Biodegradation Reveals Congeneric Total Peroxidases with Striking Distinctions. Advances in Enzyme Research, 3:66-74. http://dx.doi.org/10.4236/aer.2015.33007

 

Abstract

Peroxidases (POXs) are the key extracellular enzymes produced by crude oil degrading microbes. Knowledge of optimum conditions for POXs activity is crucial for providing effective environment for bioremediation. In this study, physicochemical properties of POXs produced by Actinomyces israelii and Actinomyces viscosus during growth on crude oil…
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Folasade M. Olajuyigbe and Kevin I. Ehiosun (2013). Production of thermostable and organic solvent-tolerant alkaline protease from Bacillus coagulans PSB-07 under different submerged fermentation conditions. African Journal of Biotechnology, 12(21):3341-3350.                      DOI: 10.5897/AJB2013.12219

Abstract

An alkaliphilic bacterium producing organic solvent-tolerant and thermostable alkaline protease was isolated from poultry litter site and identified as Bacillus coagulans PSB-07. Protease production under different submerged fermentation conditions were investigated with the aim of optimizing yield of enzyme. B. coagulans PSB-07 produced protease optimally at the…
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Effects of Processing on Seeds of Bauhinia monandra (Kurz): Mineral content, Proximate Analysis and Phytochemical Screening

By

*Agbugui, M., Oniye, S.J., and Auta, J.

Department of Biological Sciences, Faculty of Science, Ahmadu Bello University Zaria, Nigeria

Abstract: The mineral content, nutritive value and anti-nutritional factors in boiled seeds of Bauhinia monandra collected from the main campus of Ahmadu Bello University, Zaria, Nigeria were evaluated. Mineral content analysis revealed concentrations of Potassium 103.33mg/g, Iron 75.92mg/g, Calcium 56.55mg/g, Sodium 53.33mg/g, Phosphorus…
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The sex ratio, gonadosomatic index, stages of gonadal development and fecundity of the grunt, Pomadasys jubelini in the New Calabar-Bonny River were investigated. P. jubelini had a sex ratio of 1: 2.1 (male to female). Gonadosomatic index ranged from 0.33 to 7.29% with a mean of 2.89+0.08%. High gonadosomatic indices were recorded from September to October, which indicates the production period of the fish. Two stages; maturing and mature were observed for male fish while quiescent, maturing and…
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The physico-chemical characters of the New Calabar-Bonny River were investigated for two years to determine its water quality for aquaculture production and human domestic uses. Three stations were chosen to check for the variations in the selected waters parameters.  pH, Temperature, salinity, Dissolved oxygen, Alkalinity, Conductivity and Turbidity were analysed monthly from June 2011 to May 2013 using standard method s and procedures. The ranges obtained were found to be comparable to other Nigerian and African Reservoirs.…
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The morphometric parameters of Pomadasys jubelini were studied using 413 specimens from June 2011 to May 2013 using different fishing gears. The length of fish ranged from 9.60 – 55.3cm (TL). Positive allometric growth (J>1) was obtained for the length - girth relationship with growth rate values J = 1.21 and 2.28 for males and females respectively. Correlation coefficients (r) for male and female were 0.91and 0.82 respectively. “r” was positive for both sexes studies. The standard…
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The mineral content, nutritive value and anti-nutritional factors in boiled seeds of Bauhiniamonandra collected from the main campus of Ahmadu Bello University, Zaria, Nigeria were evaluated. Mineral content analysis revealed concentrations of Potassium 103.33mg/g, Iron 75.92mg/g, Calcium 56.55mg/g, Sodium 53.33mg/g, Phosphorus 47.60mg/g, Magnesium 43.33mg/g, and Zinc 01.11mg/g. Proximate composition of the seeds showed high crude protein in the boiled (25.75-31.69mg/g) and low crude fiber (7.11-10.75mg/g) in the raw samples. Phytochemical screening of the seeds showed that the concentration…
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Growth performance and feed utilization of fingerlings of Clarias gariepinus (Teugels) fed processed Pauletia monandra (Kurz) seed meal

MO Agbugui, S.J Oniye, J Auta, FO Abeke

Abstract

The growth performance and feed utilization of fingerlings of Clarias gariepinus fed diets containing a commercial feed and Pauletia monandra seed meal was studied for 56 days. The experimental diets were: diet 1 (37.50% commercial feed +12.50% P. monandra seeds), diet 2 (25.00 commercial feed +25.00 P. monandra seeds), diet 3 (12.50% commercial…
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Evaluation of a Chromogenic Medium for the Detection of ESBL with Comparison to Double Disk Synergy Test

  1. C. Ezeanya1*, N. R. Agbakoba2, C. E. Ejike3 and S. I. Okwelogu4

 

ABSTRACT

Background: Extended Spectrum Beta Lactamase (ESBL) producing bacterial strains are the major causes of nosocomial and community-acquired infections worldwide. The aim of the study was to evaluate the effectiveness of Brilliance ESBL Agar (BEA) (a chromogenic culture medium) for the detection of ESBL in comparison with…
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ORIGINAL ARTICLE

 

ANTIFUNGAL SUSCEPTIBILITY AND TEST FOR CURE OF CANDIDA SPECIES AMONG VULVOVAGINAL CANDIDIASIS PATIENTS IN A SECONDARY CARE HOSPITAL, NIGERIA

Ejike, C. E1; Agbakoba, N. R2; Ezeanya, C. C3; Emele, F. E4; Oguejiofor, C. B5 & Dirisu, J.2

1Department of Medical Microbiology, Chukwuemeka Odimegwu Ojukwu University, Awka Campus, Nigeria; 2Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus. Nigeria; 3Department of Medical Microbiology, Edo University Iyamho, Edo State, Nigeria; 4Department of Medical Microbiology and Parasitology, Nnamdi…
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SUSCEPTIBILITÉ ANTIFONIQUE ET TEST POUR LA CURE D'ESPÈCES DE CANDIDA ENTRE LES PATIENTS DE CANDIDASES VULVOVAGINALES DANS UN HÔPITAL DE SOINS SECONDAIRES, NIGERIA

Ejike, C. E1; Agbakoba, N. R2; Ezeanya, C. C3; Emele, F. E4; Oguejiofor, C. B5 & Dirisu, J.2

1 Département de microbiologie médicale, Chukwuemeka Odimegwu Ojukwu University, Awka Campus, Nigéria; 2 Département de sciences du laboratoire médical, Université Nnamdi Azikiwe, campus de Nnewi. Nigeria; Établissement en 3D de microbiologie médicale, Edo University Iyamho, Edo State, Nigéria; 4…
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Non-Albicans Candida among Symptomatic Vulvovaginal Candidiasis Women in Onitsha, Nigeria

Ejike Chinwe E1; Agbakoba Nneka R2; Ezeanya Chinyere C3; Emele Felix E4; Oguejiofor Charlotte B5

1Department of Medical Microbiology, Chukwuemeka Odimegwu Ojukwu University, Awka Campus, Nigeria. 2Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus. Nigeria.

3Department of Medical Microbiology, Edo University Iyamho, Edo State, Nigeria.

4Department of Medical Microbiology and Parasitology, Nnamdi Azikiwe University, Nnewi Campus, Nigeria

5Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Nnewi Campus,…
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ANTIBACTERIAL ACTIVITY OF GARCINIA KOLA SEED AND LEAF EXTRACT ON SOME SELECTED CLINICAL ISOLATES

Ezeanya Chinyere.C Daniel Ebakota.O

Department of Basic Sciences (Microbiology Option),

Benson Idahosa University, Benin City, Nigeria.

 

ABSTRACT

Garcinia kola seeds and leaves were screened for their anti bacterial activities using 1% hydrochloric acid, diethylether, acetic acid (ethanoic acid) and acetone. The seeds and leaves were dried and ground into powdered form. 10g of the ground seeds and leaves were in four sets. 90ml of the…
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Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) among healthcare workers in a tertiary institution in Nigeria

CN Akujobi, IA Ilo, CC Egwuatu, CC Ezeanya

Abstract

Background: Methicillin-resistant Staphylococcus aureus constitutes part of the growing health problem associated with chemotherapy because they are more difficult to treat and could transfer drug resistance to other bacteria.
Objective: This research work was carried out to find the prevalence of Methicillin-Resistant Staphylococcus aureus (MRSA) among health workers in Nnamdi Azikiwe University Teaching Hospital, Nnewi. READ MORE Download Staff Profile      


A STUDY ON SIGNIFICANT BACTERIURIA AMONG CHILDREN ATTENDING THE OUT-PATIENT CLINIC OF A UNIVERSITY TEACHING HOSPITAL, NIGERIA

AKUJOBI C.N.1, EZEANYA C.C.1*, EMEKA-OKAFOR K.M.1 AND EBENEBE J.C.2 1Department of Medical Microbiology and Parasitology, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Nigeria. 2Department of Peadiatric, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.

*Corresponding Author: Email- chi_chi34@yahoo.com

 

Abstract- Significant bacteriuria refers to the laboratory findings of >105 colony-forming units (CFU) of bacteria per mL of urine which is diagnostic of…
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Plasmid Profile of Uropathogens among Children

  1. C. Ebenebe1, K. M. Emeka-Okafor2, C. N. Akujobi2, C. C. Ezeanya2*, N. R. Agbakoba2 and C. C. Egwuatu2

1Department of Pediatrics, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra

State, Nigeria.

2Department of Medical Microbiology and Parasitology, Faculty of Medicine, Nnamdi Azikiwe

University, Nnewi Campus, Nigeria.

 

ABSTRACT

Aims: The study was carried out in order to determine the plasmid profile, antibiotic susceptibility pattern and the type of antimicrobial resistance (whether it…
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Carbapenem Susceptibility Pattern among Pseudomonas aeruginosa isolates from clinical specimens in South Eastern Nigeria

Akujobi CN, *Ezeanya CC, Madu OJ, Egwuatu CC.

Affiliation:- Department of Medical Microbiology and Parasitology, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.

Author’s contributions- All the authors contributed equally to this paper.

*Correspondence to:- Ezeanya CC. Department of Medical Microbiology and Parasitology, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.

 

Abstract:

Background: Carbapenems are a class of ? lactam antibiotics…
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EMERGENCE OF CARBAPENEM RESISTANCE AMONG EXTENDED SPECTRUM

BETA-LACTAMASE ISOLATE OF Escherichia coli FROM CLINICAL SPECIMENS IN A TERTIARY HOSPITAL, NIGERIA

 

AKUJOBI C.N. AND EZEANYA C.C.*

Department of Medical Microbiology and Parasitology, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.

*Corresponding Author: Email- chi_chi34@yahoo.com

 

Abstract- Extended-spectrum ?-lactamases (ES?Ls) are a rapidly evolving group of ?-lactamases which share the ability to hydrolyze third-generation cephalosporins and aztreonam yet are inhibited by clavulanic acid. In this study, the…
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Aim:  To  determine  indices  of  insulin  sensitivity  and  oral  disposition  index  (DIo)  derived
from  30  min  of  glucose  challenge  in  adults  with  sickle  cell  anaemia;  a  group  in  whom
there is chronic inflammation.
Study Design: Case-controlled study.
Place  of  Study:  Department  of  Chemical  Pathology  and  Department  of  Haematology,
University of Ibadan/University College Hospital, Ibadan, Nigeria.
Methodology: Twenty five (25) adults with sickle cell anaemia (SCA) in steady state and…
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Background
An understanding of the interplay between mental illnesses and metabolic
disorders is crucial. At present, in Nigeria, studies on coexistence of these
conditions are scarce. Therefore, this study was carried out to determine the
prevalence of obesity, metabolically healthy obesity (MHO) and metabolic
syndrome (MS) in adults with major mental illnesses.
Materials and methods
One hundred and twenty four patients with schizophrenia, depression and bipolar
disorder were recruited into this cross-sectional study. Blood pressure and
anthropometric indices…
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BACKGROUND The prevalence of helminth infection, which is known to affect nutritional status of
the host, varies with age. The complex interplay between ages, nutrient requirements, and infection
necessitated the need to recommend micronutrient supplementation during helminth infection among
different age groups.
OBJECTIVE The aim of this study was to determine the pattern of alteration in selected micro-nutrients in pregnant women and preschool- and school-aged children with helminth infection.
METHODS We screened 245 pregnant women and 349…
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There is at present the dearth of information on the possible  contribution of insulin resistance to scores obtained from mortality risk estimation in patients with type 2 diabetes mellitus (T2DM).  Aim: This study determined
the mortality risk scores in patients with T2DM and its relationship with insulin
resistance.  Methods: Fasting plasma glucose, total cholesterol, high?density
lipoprotein cholesterol (HDL), triglycerides, serum and urinary creatinine, glycated
hemoglobin (HbA1c), serum insulin, and urinary albumin were determined in…
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ABSTRACT

Background: Vitamin D deficiency (VDD) continues to be associated with schizophre -nia, but there is the dearth of information on the relationshipbetween the severity of
schizophrenia and plasma levels of vitamin D. This study, therefore, determined the
plasma levels of vitamin D in different severity groups of schizophrenia.
Materials and methods: Plasma level of vitamin D was determined in 60 patients with
schizophrenia and 30 apparently healthy individuals who served as controls.…
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Obesity  increases  the  risk  of  developing  a  number  of  diseases such  as  insulin  resistance,  type  2
diabetes,  hypertension, hypercholesterolemia, stroke and heart  attack.  The  aim  of  this  study  was  to
investigate the impact of ethanolic root bark extract of Anthocleista vogelii on weight reduction in high
carbohydrate  diet  (HCD)  induced  obesity  in  male  Wistar  rats. Thirty  male  Wistar  rats  were  housed  in
three  steel  cages  containing  10  rats  each. For the  period  of  obesity …
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Abstract
This  experiment  pertains  to  the  protective  role  of Vernonia  amygdalina  pre-treatment  on  some  biochemical  indices  in
dimethylnitrosamine (DMN)-induced liver damage in male albino rats. Four (4) groups of six (6) rats each were used for the
study. Group 1served as control, group 2 and 3 were pre-treated with 400mg/kg Vernonia amygdalina for one week while
group 3 and 4 each received single dose of 20mg/kg DMN (orally) after one week. The rats were…
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The present study was conducted to evaluate the protective role of ethanolic leaf extract of Annona
muricata  on dimethylnitrosamine  (DMN)-induced  hepatotoxicity  in  rat  model.  DMN  administered  rats  (single
dose orally, 12 mg/kg; on day 8) were pretreated with ethanolic leaf extract of Annona muricata (400 mg / kg
body  weight)  for  7  days  and  sacrificed  48hrs  after  DMN  intoxication.  Results  showed  that  DMN  caused  a
marked  rise  in  serum  alanine  aminotransferase  (ALT),  total  cholesterol …
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The aim of this study is to evaluate liver toxicity on exposure to n-nitrosamine precursors as well
as the effect of ultraviolet light on n-nitrosamines  and its precursors. Toxicological evaluation of the liver
following single dose treatment of wistar rat with 8.2125 mg NaNO2
/adult rat and in rats given a combined dose of 50 mgDMA-HCl and 8.2125 mg NaNO 2
 /adult rat showed a steady elevation of the liver function enzymes.
Histopathological analysis of the liver showed…
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The aim of this study is to review a procarcinogen, the N-Nitrosodimethylamine (NDMA), liver and
kidney functional enzymes (in assessing action of toxicant s such as NDMA) as well as oxidative stress parameters
(in assessing the extent of free radical damage and scavenging). Catalase and hydro peroxidase enzymes convert
hydrogen peroxide and hydro peroxides to non-radical forms and functions as natural antioxidant in human body.
Enzymes like Superoxide Dismutase (SOD) and Catalase (CAT) and…
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Objective: Chromolaena odorata is  used  in  traditional  medicine  in  Nigeria  to  remedy  malaria,
abdominal  and  cervical  pain and as  local  antiseptic  agent for  wound. This  study  was  carried  out  to  identify
bioactive  agents  and  minerals  as  well  as  in  vitro  antioxidant  activities  of  Chromolaena  odorata  leaves.
Methods: Phytochemical screening was carried out using standard procedure; mineral analysis was carried out
using Atomic Absorption spectrophotometer while reducing power and DPPH radical scavenging activity were READ MORE Download Staff Profile


Abstract
 
Several plants are utilized for medicinal and nutritional purposes. Irvingia gabonensis O’Rorke Baill leaf is used in herbal medicine for
treatment of a number of ailments. This study was therefore carried out to investigate the proximate composition, antinutritional factors,
mineral composition and amino acid profile of Irvingia gabonensis O’Rorke Baill leaf. The proximate and antinutritional factors analyses
were  done  using  standard  procedures.  The  mineral  analyses  were  done  using  flame  photometry,  titrimetic  method, …
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Abstract
Murraya koenigii known as curry leaf is used for flavouring foodstuffs and is a treasure in traditional system of
medicine.  The  study  thus  provides  in  vitro information  of  Murraya  koenigii    leaves. The  leaves  of  Murraya
koenigii  were  examined  for  their  phytochemicals,  mineral  constituents  and  for  their  in  vitro  antioxidant
activities using 2, 2-diphenyl-1-picryl hydrazyl (DPPH) radical scavenging and reducing power assays. Higher
antioxidant  potential  of  Murraya  koenigii  and  the  standard,  Vitamin  C …
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Abstract
Background:  This study was carried out to evaluate the anti-anemic effect of Annona muricata leaves on hematological parameters
in dimethyl nitrosamine (DMN)-induced fibrotic rats.
Methods: Healthy adult male wistar rats were divided into four groups. Group I rats received normal saline and served as control,
Group II rats were administered 200 mg/kg  Annona muricata, Group III received 200 mg/kg  Annona muricata orally simultaneously
with 10 mg/kg DMN, Group IV received 10 mg/kg DMN without…
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Abstract
 
Background: Liver disease and toxicity is common, especially with many drug treatments. The effect of Vernonia amygdalina ethanolic
leaf extract post-treatment on rats pre-treated with dimethylnitrosamine (DMN) was evaluated.  
Methods: Male wistar rats were orally administered DMN (single dose of 25 mg/kg) on first day and thereafter post-treated with 100 and
200mg/kg ethanolic leaf extract of Vernonia amygdalina for seven days. Analysis of serum concentrations of albumin, total protein, total
bilirubin…
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Abstract
 
Background: Pterocarpus mildbraedii is used in some Nigerian tribes in the treatment of headaches, pains, fever, convulsions, and res-piratory disorders. This study was carried out to ascertain the phytochemicals, minerals and in vitro antioxidant activities of Pterocarpus
mildbraedii leaves.  
Methods: Qualitative phytochemical screening was carried out using standard procedures while Mineral analysis was carried out using
Atomic  Absorption Spectrophotometer  (AAS).  Also,  antioxidant  activities  of Pterocarpus  mildbraedii leaves  were  evaluated  using  re-ducing power…
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ABSTRACT
Plants  of  medicinal  properties  have  been  recognized  to  have
therapeutic  effects  as  well  as  toxic  side  effects.  The  present  study
aimed  to  investigate  the  effect  of  aqueous  and  ethanolic  extracts  of
Cymbopogon  citratus  on the  lipid  profiles  of  normal  rats. The  lipid
profiles  of  rats  treated  with  both  ethanolic  and  aqueous  extracts  of
lemon  grass  as  observed  in  table  3.  The  Total  cholesterol,
Triglycerides,  High  density  lipoprotein  (HDL)  and  low …
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ABSTRACT
This  study  aimed to  assess  the  effect  of  ethanolic  leaf  e xtract  of Ve rnonia  amygdalina (VA E) post-treatment  on
biochemical  indices in dimethylnitrosamine (DMN)-ad ministered albino rats. A total of thirty (30)  male  rats shared
into five (5) groups were used. Group 1 rece ived distilled water only; group 2 received 200 mg/kg  VA E only wh ile  
group 3 rece ived a single oral dose of 25 mg/kg DM N on…
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Gnetum africanum, a common soup vegetable in Nigeria is also been used in the treatment of enlarged spleen,
sore throats, deduction of pains of child-birth, antidotes to some forms of poison and snake bite. This study is to ascertain
phytochemicals and minerals present in the leaves of Gnetum africanum in addition to in vitro antioxidant activities using
standard  procedures.  The  result  of  the  phytochemicals  present  revealed  the  presence  of  flavonoids,  saponins,  tannins,
alkaloids  while …
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Abstract
 
Background: Celosia argentea, a traditional vegetable in West and Central Africa is widely grown for ornamental purpose in the tropics
and subtropics such as in Malaysia. The aim of this study is to determine phytochemicals, mineral composition and in vitro antioxidant
activities of Celosia argentea leaves.  
Methods: Qualitative phytochemical screening was carried out using standard procedures, Mineral analysis was carried out using Atom-ic  Absorption  Spectrophotometer  (AAS)  while  antioxidant  potential,  free  radical  scavenging …
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ABSTRACT
The  present  study  sought  to  undertake  the  phytochemical  analysis  (using  standard methods of analysis), proximate and mineral composition as well as in vitro antioxidant properties  (involving  inhibition  of  DPPH  and  reducing  power  ability)  of  aqueous  leaf extract  of  Telfairia  occidentalis consumed  in  Ekpoma,  Edo  state,  Nigeria.  The preliminary  phytochemical  analysis  showed  that  the leaf  of  T.  occidentalis contains flavonoids, tannins, saponins, alkaloids and phenolics. Quantitative analysis showed that phenol,  flavonoids,  tannins,  alkaloids  and  saponins  in  percentage …
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ABSTARCT

This  study  was  carried  out to  investigate  the  effects  of  ethanolic  leaf  extract Annona  muricata (soursop)  on N,N-dimethylnitrosamine  (DMN)-induced  liver  fibrosis  in rats.  Four groups  of  Wistar albino rats  (12 rats/group)  were used for the study. One group received intra-peritoneal injection of 10mg of DMN/kg body wt. thrice a week (on the first three  days)  for  14  days,  in  addition  to  the  extract  at  a  dose  of  200mg/kg  body  wt.  given  by  gavage.  A  second  group received …
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Abstract
 
Background: The occurrence of dietary and environmental chemicals such as dimethylnitrosamine (DMN) in drinks and foods including
fish and meat as well as fresh supermarket products is well established. This study evaluated protective effect of ethanolic leaf extract of
Vernonia amygdalina (VAE) on liver synthetic molecules, kidney function and hematological parameters in acute dimethylnitrosamine
(DMN)-induced hepatic toxicity in wistar male rats.  
Methods: Experimental rats divided into four groups of six rats…
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Abstract
 
Background: Hepatic fibrosis is a pre-pathologic state of cirrhosis, which plays a pivotal role in the pathogenesis of hepatocellular car-cinoma  (HCC).  This  study  was  carried  out  to  evaluate  the  hepatoprotective  effect  of Annona  muricata leaves  on  extracellular  matrix
(ECM) accumulation, lysosomal membrane integrity and liver damage in dimethylnitrosamine (DMN)-induced fibrotic rats.  
Methods: Healthy adult male wistar rats were divided into four groups. Group I rats received normal saline and served as control, Group…
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Abstract
 
Background: Hepatic  fibrosis  is  the  accumulation of  extracellular  matrix  protein,  or  scar,  in  response  to  acute  or  chronic liver  injury.
This study investigated the effect of ethanolic leaf extract of Vernonia amygdalina on extracellular matrix protein: hyaluronic acid (HA),
liver synthetic molecules: total protein (TP), albumin (ALB), total bilirubin (TB) as well as lysosomal membrane stability: acid phospha-tase (ACP) in dimethylnitrosamine (DMN)-induced fibrotic rats.  
Methods: Wistar albino male rats were intraperitoneally injected…
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Abstract
 
Background:Dimethylnitrosamine  (DMN)  is  a  potent  hepatotoxin,  carcinogen  and  mutagen  which  exerts  carcinogenic  effects  and  in-duces hepatic necrosis in experimental animals through metabolic activation by CYP2E1. This study thus evaluated efficacies of Annona
muricata pre-treatment on acute dimethylnitrosamine (DMN)-induced anemia and biochemical alterations in male albino rats.  
Methods:Four (4) groups of six (6) rats each were used for the study. Group 1 served as control and was untreated, group 2 and 3 were
pre-treated with…
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ABSTRACT
This  study  investigated  the  phytochemicals,  trace  and  mineral  contents  of  leaves  of Vernonia  amygdalina obtained
from  Benin  City,  Edo  state,  Nigeria.  The  mineral  analysis  was  done  using  Atomic  absorption  spectrophotometric  analysis
method while phytochemical composition was determined using standard methods. The results of the phytochemicals analyses
are  as  follows:  saponins  (2.50%),  alkaloids  (1.03%),  flavonoids  (11.50%), tannins  (0.17%),  ascorbic  acids  (46.64mg/100g),
beta-carotene  (9.05mg/100g),  and  reducing  sugars  (45.60%)  while  the  mineral  analysis  reveals  the …
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Proximate composition  and  phytochemical analyses  were  carried  out  on  the
leaves of Annona  muricata using  standard  methods.  The  result of  the  proximate  composition
showed  that  the  leaves contained 88.99% dry  matter,  11.01%  moisture,  25%  crude  protein,
14.96%  ash,  22.20%  crude  fiber, 21.22  %  fat  and 16.62%  carbohydrate  contents.  The
phytochemicals  detected  in  the ethanolic  leaf  extracts  were flavonoids,  alkaloids,  cardiac
glycoside, tannins, triterpenoid, saponin and reducing sugar. The findings indicate that Annona READ MORE Download Staff Profile


Abstract
In this study, the protective effect of   Vernonia amygdalina ethanolic leaf extract against hepatic fibrosis induced by repeated
intermittent administration of  Dimethylnitrosamine (DMN) was investigated in rats. A total of  48 rats divided into 4 groups
were used. Group 1 served as control, Group 2 received 200mg/kg Vernonia amygdalina only for 14days, Group 3 received
200mg/kg Vernonia amygdalina for 14 days followed by intraperitoneal administration of 10mg/kg DMN on first three days
of…
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Abstract
Introduction: Dimethylnitrosamine (DMN) is a potent hepatotoxin, carcinogen and mutagen whose toxicity is mediated by its
reactive  metabolites  and  not  by  the  parent  compound.  The  antihepatotoxic  efficacy  of  ethanolic  leaf  extract  of Vernonia
amygdalina against DMN-induced liver damage in rats thus, needs to be investigated.  
Methodology: Rats were given DMN, at a single dose of 12 g/kg body weight orally on day 8 after pretreatment with 400mg/kg
Vernonia amygdalina for 7days and…
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Aim: This study aim to evaluate the modulatory ef fect of ethanolic leaf extract of  Annona muricata against dimethylnitrosamine (DMN) -induced hepatic toxicity in rats.    

Methodology:  Twenty- four (24) male albino rats divided into four (4) groups of six (6) rats each were used for the study. Group 1 served  as control and was untreated, group 2 and 3 were pre -treated with 400  mg/kg Annona muricata  for one week while group 3 and 4 each received a single…
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ABSTARCT

The protective role of ethanolic extract of unripe pulp of  Carica papaya (fruit), against potassium-bromate induced tissue damage in wistar rats was investigated. The animals were grouped into four groups (A, B, C, D) of five rats. Group A was administered 1  mL of 0.25 M sucrose solution. 60 mg/kg of Potassium bromate KBrO3 was administered orally to rats in groups B,  C and D. Groups C and D were pretreated with 250 and 500 mg/kg of the extracts for…
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ABSTRACT

The aim of this study is to exam ine the phytochemical screening, ch emical composition and antimicrobial activities of ethanol extracts of both the leaves and stems of  Cymbopogon citratus.  For proximate analysis,  results for the leaves on the Moisture content, ash content, fat content, crude fibre, crude protein and carbohydrate were: 13.50, 11.17, 10.00, 19.54, 17.50 and 28.29% while that of the stem were: 7.98, 14.29, 13.50, 12.5, 17.50 and 34.23%, respectively. Also, the extracts was screened against…
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ABSTARCT

Many plants with reported medicinal value have been demonstrated to exert a protective effect on the liver and some, with the ability of lowering the blood lipid level have also been elucidated. This study shows the effect of ethanolic and aqueous extracts from  Vernonia amygdalina  on the plasma lipid profile as well as on the level of the liver biomarker in the plasma of normal rats. The animals were distributed into two sets of four groups with five animals…
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ABSTARCT

Malaria vectors of the Anopheles gambiae complex are made up six species of mosquitoes that are stable and are highly efficient vectors. This group comprises of major and minor vect ors, some of which are responsible for transmission of the most deadly strain of malaria parasite, Plasmodium falciparum . The evolutionary history of this species group was inferred using publically available DNA sequence data. Th e retrieved sequences were aligned usi ng CLUSTAL W; evolutionary history was inferred using…
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ABSTRACT

This study was undertaken to assess the molluscicidal potency of ethanolic and aqueous extracts of roots, leaves, bark, and seeds of Ficus exasperata(Vahl) against juvenile and adult Biomphalaria pfeifferithat are intermediate hosts of schistosome species causing intestinal schistosomiasis. Snails were collected and reared in the laboratory. Plants were identified, authenticated, andMphytochemically screened. Cold water and organic solvent (ethanol) extraction of different parts of the plant were carried out. The walls of the digestive tract of the snails were histopathologically…
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Abstract Microbial contamination is considered the most significant hazard associated with food. Data on pathogens present in foods are needed to provide valuable information on the exposure of consumers to certain food borne pathogens. Also, consumption habits among consumers may increase the risk of health hazards. This study aimed to assess some practices, signs and symptoms associated with consumption of soaked garri among university students, to also determine the presence and virulence characteristics of some bacteria in garri…
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Abstract
Introduction: The most common oral hygiene aid used to improve the oral health of an individual is the toothbrush. Hence, it could play a role in initiation and transmission of infections and diseases. This study aimed at investigating the presence of haemolytic bacteria on used toothbrushes.
Methods: A close-ended questionnaire was designed and distributed to a hundred Nigerian students. This was employed to ascertain the attitudes of students towards their toothbrush. Twenty samples of already-used toothbrush (1-3…
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Abstract
Screening of hydrocarbon degrading microorganisms from oil contaminated soil was studied and the samples were obtained from three Mechanical Workshops in Awka, Anambra State. The microorganisms were isolated using the pour plate method by selective enrichment technique. All samples were cultured in solid media with crude oil as a sole carbon and energy source to isolate hydrocarbon utilizers from the sample collected from different mechanic workshop. The isolate were identified on the basis of their colonial and…
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Abstract Pseudomonas aeruginosa strain ANSC, a non-genetically modified bacterial strain isolated from soil was used to study and evaluate biosorption potentials for hexavalent chromium (Cr[VI]) from aqueous solution. Living, heat-killed, and permeabilised cells were all used and found to be capable of reducing and sorbing Cr(VI). The influences of initial Cr(VI) ion concentration (50–150 mg/L), contact time (2 h, 10 min intervals), pH (2–8), temperature (30–60°C) and biosorbent mass (1.0–5.0 g/l) were reported. Adsorption of Cr(VI) is highly…
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Abstract: The response of serum alkaline phosphatase (ALP) activity in albino rats following oral administration of three Nigerian strains of Lactobacillus was investigated. Twenty albino rats weighing between 50g – 65g were grouped into five (groups BD, BM, BL1, BL2 and BL3) without bias. Three groups were orally dosed with the three strains of Lactobacillus each, while two groups received basal diet and sterile skimmed milk, respectively for six days. After which a post treatment period of ten…
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Abstract: 413 samples of Pomadasys jubelini were obtained from the New Calabar-Bonny River and examined over a period of twenty four months. The length ranged from 8.50cm - 47.60 and the weight from 17.00g - 2320g. Females were longer and heavier than males. There was a strong and positive relationship between fish length and weight (r) = 0.91 for males and 0.99 females, and b value (b<3) indicating a negative allometric growth.The monthly condition factor (K) ranged from…
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Abstract.

The sex ratio, gonadosomatic index, stages of gonadal development and fecundity of the grunt,Pomadasys jubelini in the new Calabar-bonny River were investigated. P. jubelini had a sex ratio of 1: 2.1 (male to female). Gonadosomatic index ranged from 0.33 to 7.29% with a mean of 2.89±0.08%. Highgonadosomatic indices were recorded from September to October, which suggested the spawning periodof the fish. Two stages, maturing and mature were observed for male fish while quiescent, maturing and mature were…
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