green oxalate onto activated carbon from snail shell was carried out. The cleaned Snail shell was carbonized at 400oC, crushed and sieved before it was activated with 0.1m HCl at 800oC in a furnace. Batch adsorption experiment was carried out at variable…
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In this work, statistical modeling and optimization of biodiesel production from Azadirachta Indica(neem) using co-solvent technique via a two-step transesterification process was carried out. Neem oil was extracted from neem seeds and properties such as moisture content, specific gravity, acid value, saponification value and iodine value were determined. The experimental design used was Central Composite Design. The range of factor levels used for the Central Composite Design were reaction temperature (30°C to 46°C), catalyst amount (0.8% to 1.2%, w/w),…
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Isothermal, kinetic and thermodynamic studies of the adsorption of erythrosine dye onto activated carbon from Periwinkle shell was carried out. The Periwinkle shell were washed, dried, carbonized at 400oC, crushed, sieved, chemically activated at 800oC, cooled, washed and dried at 110oC. Variable influencing factors, such as contact time, temperature and concentration were studied through singlefactor experiment, while other factors are kept constant (at 30min, 30oC and 50mg/L) in each adsorption experiment.
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This study presents the application of ternary phase diagrams to tropical almond biodiesel components separation and purification at two temperatures. The seed oil was extracted mechanically and alkaline transesterified to produce biodiesel. The oil and biodiesel were characterized using standard methods. Tie lines and binodal solubility curve data were determined using modified cloud point titration procedures. Gas chromatographic method was employed in the analysis of the phase compositions. The mixture of biodiesel, methanol and glycerol were investigated at 20…
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The composition of jatropha oil and biodiesel has attracted extensive research. However, fewer studies have been reported on the functional properties of the oil and biodiesel. In this research, the functional properties and physicochemical composition of jatropha oil and biodiesel were investigated. The functional properties were studied using spectroscopic method while the oil and biodiesel were subjected to various physicochemical tests. The results obtained revealed high levels of unsaturated fatty acid with linoleic and oleic acids…
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This paper presents the results of an experimental study of the effects of surface texture on the optical and light trapping properties of silicon wafers. Surface texture is controlled by anisotropic etching with potassium hydroxide (KOH) and isopropyl alcohol (IPA) solutions. The anisotropic etching of (001) crystalline silicon wafers is shown to result in the formation of {111} pyramidal facets on the surfaces of the wafers. A combination of profilometry, optical microscopy, scanning electron microscopy, and atomic force microscopy…
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Tigernut (Cyperus esculentus) seeds were examined for its starch composition and applicability as biomaterial in hybrid composite materials development. The physicochemical properties of the starch extracted were then compared with standard industrial maize starch. The starch was isolated using 1% w/v sodium metabisulphite solution and the obtained starch was found to be a brilliant white, crystalline, non- hygroscopic powder with yield of about 21%. The starch percentage solubility at 90°C was 2.36 with a swelling power of…
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We investigate the effect of surface texturing on the light trapping properties of Silicon wafers as a function of reflection reduction and surface morphology. This was achieved by structuring a random square-based pyramids pattern on the surface of Silicon substrate using anisotropy etching. The light trapping effect was optimized for silicon solar cells by investigating the dependence of the silicon surface texturing on the process parameters such as etchant concentration, etching time and temperature. We study the surface morphology…
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Ginger (Zingiber officinale) roots were crushed and the starch extracted in order to determine its starch composition and use in biomaterials development as hybrid composites. The physicochemical properties of the isolated starch were then determined and compared with standard industrial maize starch. The starch was isolated using 1% w/v sodium metabisulphite solution and the obtained starch was found to be a white, crystalline, non- hygroscopic powder with yield of about 18%. The starch percentage solubility at 90?C…
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The extraction and characterization of chitin from four sources of Nigerian origin was investigated. Chemical demineralization and deproteinization was done to obtain the chitin. Proximate analysis, XRD and SEM analysis were conducted on obtained chitins. The investigation revealed that the shrimp had the highest yield of chitin of 8.15%, crab, crayfish and periwinkle had yields of 7.8%, 2.88% and 0.44% respectively. The proximate analysis showed that chitin from shrimp had highest moisture and protein content of 8.70% and 4.16%…
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The production of methanol from different sources as alternate biofuel as well as gasolineblend fuel component will help in mitigating the adverse effect of using gasoline from hydrocarbon as fuel for internal combustion engines. Kinetics and thermodynamics studies were carried out in this study using the process of hydrolysis of methyl acetate catalyzed with hydrochloric acid to produce methanol. The method employed was backward-titration which was used to determine the concentration of methyl acetate catalyzed with hydrochloric acid in
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In this work, the effect of adding pumice powder to recycled beverage cans as reinforcement from 2 to 8 wt% in steps of 2 wt% was investigated. Manual stir casting technique was employed. Some mechanical (rockwell hardness, impact strength, tensile strength) and physical (density) properties were determined using standard methods. At 8 wt% pumice addition, an increment of 11.08% and 28.39% on hardness and tensile strength, respectively of the unreinforced recycled beverage can were recorded. However, the impact strength…
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This work compared the production of oil from the pericarps (peels) of avocado apple using steam distillation and extraction (direct and indirect leaching) with respect to the yields. An improvised steam distillation set-up was used at three different steam heating rates. It entailed the comminution of the sample material suspended on a grid (perforated metal plate) 90mm above the water level and the application of steam through the material. The steam percolated the material and subsequently vaporized the oils…
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Sawdust and rice husk are available in abundance and indigenous in Nigeria but have not been exploited because they cannot be used directly in combustion processes due to their loose form unless by pelleting or briquetting. This experimental study assesses the potential of pellets from sawdust (SD) and rice husk (RH). Pallet samples collected from mills were thereafter optimized in ratios (i.e. 90%RH:10%SD, 80%RH:20%SD, 70RH:30SD, 60%RH:40%SD, 50%RH:50%SD, 100%RH and 100%SD) using mixing ratio optimization model. Seven…
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Sawmill dumpsites are characterised by combustion of wood wastes which pollutes the environment. In this study, five tropical species of wood wastes were collected from sawmill dumpsites in Asaba Metropolis and used for experimental analysis. The samples were chopped into particle sizes of 0.3 to 0.5 micrometres and analysed in accordance to ASTM standards. The analyses include the calorific value (CV), proximate and ultimate analyses. Data generated from the analyses was used to evaluate the potential carbon iv oxide…
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This work compared the extraction of oil from the pericarp (peels) of avocado apples using two different solvents namely n–hexane and anhydrous ethanol. Direct and indirect leaching methods were used to extract the oil from the pericarp of the apples. The extraction was carried out at different particle sizes, times, and boiling points of the solvents. These were as follows: 0.75mm,1.00mm, 1.59mm and 2.00mm; 30, 60, 90 and 120 minutes; 600C and 780C for n–hexane…
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In this paper, the surface morphology of textured silicon substrates is explored. Prior to the surface morphology analysis, textured silicon substrates were obtained by KOH anisotropic texturing of polished silicon wafers. This was achieved by investigating of the dependence surface texturing on the process parameters; etchant concentration, etching time and temperature. The surface morphology of the textured silicon samples was obtained using atomic force microscopy that was operated in the tapping mode. The resulting atomic force microscopy (AFM) images…
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Adsorption of Congo red dye onto activated carbon from periwinkle shell was carried out to see if the activated carbon from Periwinkle shell will provide a good alternative for the commercial activated carbon in the adsorption of Congo red dye from polluted water. Periwinkle shells carbonized at 400oC and activated with 0.1M HCl at 800oC in a furnace was used as adsorbent to remove Congo red dye from aqueous solution. The effect of the variables:…
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Accurate knowledge of the components in the purification of biodiesel is important in achieving consistency in quality for the separation and purification process. In this paper, ternary phase diagrams were used to study the phase separation and purification of tropical almond biodiesel at temperatures of 20 C, 30 C and 40 C. The biodiesel was produced using alkaline transesterification of the seed oil. The biodiesel…
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We investigated the properties of zinc sulphide thinfilms deposited using a field assisted electrostatic spray pyrolysis deposition apparatus at an optimized substrate temperature, time, pressure and flowrate of 300oC, 10minutes, 1atm and 0.5ml/min respectively. The ZnS thin films were there-after annealed at 350oC for 3hours. The influence of process parameters on the properties of the ZnS thinfilms were investigated using x-ray diffractometry, uv-spectrophotometry and profilometry. The morphology of the films and the nano-mechanical properties of…
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Kinetic data obtained from acid demineralization (using 1.25 N hydrochloric acid solution) of deproteinized exoskeleton of shrimp was fitted to the shrinking core models for heterogeneous reactions. The element of interest was calcium which was the most abundant element in the deproteinized shrimp (66.27%) and the mostly affected by the demineralization. Experimental kinetic data was fitted to the shrinking core model for fluid-particle reactions. Chemical reaction controlled mechanism gave the best predictive model, as depicted by the fit (R
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In recent years, the use of multimedia contents (image, audio, video and text) is rapidly increasing with the high growth and widespread use of the Internet and information technology. Due to this fact, tampering and illegal distribution of digital contents is inevitable because of their digital nature and as such it becomes imperative to devise mechanisms to protect such contents. Several mechanisms that have been proposed for data hiding are cryptography, steganography and watermarking. One of such mechanisms that have…
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Transmission of multicast traffic (such as video, data and voice services over World Wide Interoperability for Micro Wave Access “WiMAX” aims to make multicast traffic available to users anywhere, anytime and on any device. The major challenges of transmitting wireless traffic over WiMAX network through convention multicast schemes are throughput fluctuation (Variations) among the subscribers within the network coverage, unfair distribution of network resources, delay, delay jitter and packet drop because they are placed in different locations from the Base…
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This paper presents the novel structural analysis of ball-on-sphere system using bond graph technique. The structural analyses carried out are controllability and observability of the system. To achieve these analyses, the system was modelled using bond graph modelling technique. In the modelling procedures, the various subsystems, storage elements, junction structures, transformer elements with appropriate causality assignments and energy exchange that make up the ball-on-sphere system were identified and modelled. The structural controllability and observability properties of the system…
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The challenge in optimal resource allocation to mobile Worldwide Interoperability for Microwave Access (WiMAX) subscribers has not been fully overcome by researchers. This research aimed at developing an optimal scheduling algorithm for WiMAX resource allocation based on an improved Particle Swarm Optimization (PSO) technique. In this work, an improved PSO based technique for allocating subcarriers and Orthogonal Frequency Division Multiplexing (OFDM) symbols to mobile WiMAX subscribers is proposed using sub-group formation. The entire WiMAX network environment is sub-divided into 7…
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This paper studied external-source-excited vibration response of double-bay multi-storey building frames for the effect of joint stiffening on bending moment and joint displacement. One of the frames has normal rigid joints. Three others of the frames have stiffened joints of stiffened lengths: 275mm, 425mm and 775mm respectively. Lumped mass system was the dynamic model adopted. The frames were modeled as those with flexible horizontal members, permitting rotation of joints and having multi degrees of freedom (MDOF). Classical displacement method of…
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This paper presents exact solution of displacement fields of thick rectangular plate which was obtained using traditional third order refined theory for the bending of rectangular plates with different support cases under general boundary conditions. The aim of study is static bending analysis of an isotropic rectangular thick plate using analytical method. Total potential energy equation of a thick plate was formulated from the first principle. This equation was subjected to direct variation to obtain three simultaneous direct governing equations…
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Electrical capacitance tomography (ECT) and gamma ray densitometry have found applications in multiphase flows as both have been used to visualize flow patterns in the process, nuclear, chemical and oil-gas industries. However, liquid viscosity is often limited to about 10 cP in most of these applications. This study evaluates the suitability of ECT in the monitoring of multiphase flow consisting of heavy-oil (up to 7500 cP) and gas. Heavy-oil is of interest because of its huge reserves, increasing world energy…
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Slug flow is one of the most critical and often encountered flow patterns in the oil and gas industry. It is characterised by intermittency which results in large fluctuations in liquid holdup and pressure gradient. A proper understanding of its parameters (such as slug holdup) is essential in the design of transport facilities (e.g. pipelines) and process equipment (slug catchers, separators etc.). In this paper, experimental investigation of slug liquid holdup (defined as the liquid volume fraction in the slug…
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Polymer catalyst for biodiesel production was developed and the catalytic activity dependence an preparation conditions, ranging from absorbed radiation dose, …..
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Radiation-induced graft polymerization of 4-chloromethylstyrene onto a polyethylene substrate was carefully performed…
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This study deals with the mass transfer evaluation of the graft polymerization of 4-chloromethylstyrene unto irradiated polyethylene substrates…
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Methyl ester also called biodiesel is an alternative fuel for diesel engine that is produced from renewable agricultural products…..
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Biodiesels obtained from renewable energy sources are considered to be good alternatives to traditional fuel sources due to their environmental friendliness. Purification of the biodiesel upper-rich phase composition after transesterification is often influenced by some parameters. This study investigated the influence of temperature and time interval on the purification of biodiesel upper-rich phase mixture composition of Jatropha oil biodiesel system consisting of Jatropha oil biodiesel, methanol, glycerol at (20°C, 25°C, 30°C, 35°C, 40°C, 45°C, 50°C, 55°C, 60°C) and (2, 4,…
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Abstract:
Oil reserve is defined as an estimate of how much oil can ultimately be recovered. This broad definition is also called oil in place. It includes undiscovered or "yet to find" reserves. It's based on the probability of finding reserves in certain geological areas. It also assumes that new types of technology will make it economically feasible to extract the oil. Nigeria oil and gas reserves have increased to 37 billion barrels. It can also be said…
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The major motive of any business organization is to make profit. This is particularly so in the private sector. In the public sector, the forefront aim is to satisfy the needs of the masses/to achieve either of the managerial aims; the management of the enterprise should put its axe together. This entails planning, a good planning initiative commences with adequate budgetary process. This calls for a team effort. The team should be ggg embracing. The decision making process…
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Decision making is an important aspect of planning. Planning has primacy in the functions of management: planning, organizing, staffing, leading and controlling. All these are activities of Production, Marketing, Finance, Human Resource Management, Purchasing and Innovation which are activities in management. Decisions are unique in the sense that there must be courses of action to select from. Moreover, decisions are of three types namely those under certainty; uncertainty and risk. In certainty, the decision maker is sure of…
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Demand is the willingness and ability of buying a product at a given price within a specific period of time. It is a flow concept as it has quantity and time dimensions. Demand forecasting is not a process that involves a crystal ball. It rather involves carrying forward past data. The main objective of the paper is to do a theoretical review of demand forecasting, solve a demand forecasting example and to set a multiple regression example. Price…
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The interest of this work was aroused by the perception of workers’ wrong attitude towards female executives in Nigerian organizations. Considering the fact that female executives are not adequately represented in firms, it became imperative that organizations where females are in management positions should be looked into and suggestions made for the right attitude by workers to female executives to bring out the best in them in the performance of their jobs. This assignment, therefore, is undertaken to…
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The purpose of going to business is to make profit, thus cost minimization and profit maximization one of the objective of management. The more cost is reduced the greatest the profit, thus, the purpose of transportation cost to the barest contribution or profit to the organization. The transportation problem is a peculiar form of the linear programming model, however solve using a different technique apart from the simplex method
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Third world is that part of the world that has developing countries located in Africa, Latin America and Asia. Third World Development consists of an increase in socio-economic condition from a lower to a more desirable state of Development challenges are barriers, setbacks, problems and threats that make it difficult for the countries in the Third world not to move from a lower socio-economic condition to a higher one. A millennium consists of 1000 years. So the Third…
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This paper takes a critical at the dimensions of social responsibility and the challengers of enforcing organizational goals in Nigeria. Business leaders are expected to develop strategy policy as regards it role in the environment where it is operating. Such policy formulation is in the area of social responsibility that would help to care for host community. Emphasis must be on the needs of the society, implement the programme develop and fully communicate its activities through social audit. It is…
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Research is the process of investigating or finding out something new or improvement of poor result in a systematic way thereby increasing knowledge. National development is that increase of the national income or total volume of production of goods and services of a country accompanied by improvements in the total standard of living of the people. It is a total upward structural shift of the social system in terms of a capacity to produce, supply, distribute and consume…
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Motivation is a will to do. It is a psychological process. It aimed at achieving organizational objectives. Abraham Maslow (2008) identified 8 needs. The new needs are those of knowledge and understanding, duty and esthetic, and transcending going beyond ordinary.
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In the early 1900’s when banking business was introduced into the country, the business wasn’t that progressing and attractive, not until in the 1960’s when training and manpower development has taken place. With so many people highlighting on the impact of training and manpower development in an organization, Iyayi (2005) described training and manpower development as the activities that are directed towards providing the people of an organization with the skills, attitudes and motivation needed to perform…
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The Human Resource is the totality of the skills, potentialities and competencies of the human being. The human resource along with other resources materials, money, time, knowledge and energy are the inputs which have to be transformed by the process made up of machines, methods and maintenance to get the outputs of goods and services. Human Resource management is the function area that is responsible for managing people at work. Right from 1903 to 2010, the crude oil…
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The study examines the effectiveness of queuing models in the establishment and services organizatins. It attempts to find a balance between cost associated with having to wait for service and the costs of providing a fast service. Queuing model are set of tools for analyzing such problems concerned with providing service to customers. It helps to determine the Distribution of inter-arrival times. Distribution of service times and gives the number of servers. Queuing theory system have an effect…
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The main objective of the paper is to do a theoretical discussion of Due Process in government procurement vis-à-vis challenges its implementation in Nigeria. It becomes necessary that contract; government agency should have proceedings, transparency without favouritism and corruptible tendencies, which should be implementable and enforceable in Nigeria. The paper examines the background problems and subsidiaries objectives of Due Process Procurement in Nigeria where also revealed. The assessment of the operational structure(s) arising from the different levels of…
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The main objective of this work is to critically examine cost-effective reporting standard in small and medium scale enterprises in Nigeria. There is a considerable debate over the appropriate role for small and medium scale enterprises. Years back, there has been controversy as to whatever the current financial reporting system for small and medium scale enterprise (SMEs) is adequate. It has been encountered in different countries of the world, including Nigeria. This study tries to look into the…
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The study of consumer behavior is primarily concerned with finding out how individuals, groups and organizations select, buy, use and dispose of goods, services, ideas or experiences in orders to satisfy their needs and wants. This paper focuses on the impact of the process of producing and consuming of goods and services on the environment in which we live. It traces the history of the concept of the environment and examines the sustainability questions in an attempt to…
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A business is defined as a venture which is established by an Individual, a group, an Organisation, a Government or a set of Government with the aim of making profit. Profit is the positive difference between total revenue and cost. Research means to search again or to do a cursory examination on an event, an activity or an issue of interest. Sustainable Development means ensuring that the needs of the present generation are satisfied without hampering the future…
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Business is any activity that an individual engages into that leads to the satisfaction of human wants. Poverty is a situation when a person is not able to meet up his basic needs of food, shelter, clothing and subsistence employment; he can be said to be a poor person. The dimension of poverty ranges from infinity complex and personality adjustment problems. Sometimes some beg like children, some may not even eat what she or he wants to eat.…
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African countries are that part that has developing in which people with lowest income improves in material welfare. It has increase overtime of an economy’s capacity to produce those goods and services needed to improve the wellbeing of the citizen in increasing numbers and diversity. African production development merely is the creation of utility in both micro and macro and economic studies that are estimated nationally at least, the varying levels of production and output both the firm…
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The research work is to determine the feasibility and viability of establishing a new soap manufacturing firm in Shomolu-Bariga area of Lagos State. From investigation, it has been revealed that customers around Shomolu-Bariga of Lagos State Area are not satisfied with the quality of soap available in the market. Besides, most of the soap manufacturing firms in Lagos are sited in more popular areas like Ikeja, Lagos Island, etc. Therefore, the significance of this project or feasibility study…
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Abstract Introduction: To determine the possibility of utilizing total lymphocyte counts (TLC) instead of CD4 counts in the initiation and management of patients with HIV on highly active antiretroviral therapy (HAART). The commencement of HAART CD4 lymphocytes has been employed in the management HIV. However it has been found that determination of CD4 counts is expensive and somewhat laborious to perform in already overburdened healthcare systems especially in the developing countries. Methodology: Five hundred and three (503) consenting patients already…
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Background: Transfusion-transmissible infectious agents such as hepatitis B virus (HBV), human immunodeficiency virus (HIV), hepatitis C virus (HCV) and syphilis are among the greatest threats to blood safety for transfusion recipients and pose a serious public health problem. This cross-sectional study was undertaken with the aim of determining the seroprevalence of HIV, HCV, hepatitis B surface antigen (HBsAg) and syphilis and correlates the findings with sex and age to ascertain the associations, if any, in the occurrence of the pathogens.
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ABSTRACT Purpose: Feto-maternal haemorrhage (FMH) is a complication of pregnancy and large FMH may lead to life-threaten- ing anaemia in the fetus or newborn. In addition, exposure of Rhesus (Rh) D negative women to small amounts of fetal Rh D positive red cells during pregnancy or delivery may result in sensitization with its attendant problems of isoim-munisation. In most cases, the cause of FMH IS unknown. Through this study, we sought to determine if placental weight & diameter have any…
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ABSTRACT A cross-sectional study was carried out in Ilie community of Olorunda Local Government Area in Osun state, southwestern Nigeria to comparatively evaluate the presumptive diagnosis of schistosoma infections using microscopy as gold standard. One hundred and thirty seven consented primary school children aged 4 to 15 years were examined for presence of schistosome eggs. The urine samples were analyzed with urinalysis strips for microhaematuria as indicators of presumptive diagnosis for urinary schistosomiasis while fecal samples were analyzed with fecal…
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Urinary Schistosomiasis is a parasitic disease of public health importance in Africa affecting children. It relationship with malnutrition is well pronounced in Nigeria and impairs growth of the affected children or persons. This work investigates the nutritional status of children infected with urinary schistosomiasis. The Anthropometric indices of the studied children were determined according to standard procedures and related to intensity of Schistosom. haematobium infection. The weight, height and Age were Anthropometric indices used in this study. A total of…
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Antioxidant, hypolipidemic and Hypoglycemic Effect of Ethanol Leaf Extract of Chrysophyllum albidum on Streptozotocin- Induced Diabetic Rats.
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Abstract Background Stroke is a very troubling illness as it not only disables its victim, but also kills most of them outright. Its rate is increasing in the developing countries and this drains their finances. As a result many seek management of their condition in herbal homes. But of recent there is a preference to herbal medicine by most stroke survivors, irrespective of social status. This is a new phenomenon. Objective The main objective of this study was to assess…
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ABSTRACT Despite important progress in the management of diabetes using synthetic drugs, many traditional plant treatments are still being used throughout the world. The goal of this study was to investigate the effects of ethanol leaf extract of Chrysophyllum albidum on the histology of the pancreas of STZ-induced diabetic rats. Thirty rats divided into six groups (n=5). Groups I and II received only normal saline; group III received 2 mg/kg of glibenclamide; groups IV, V and VI received 125, 250,
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Abstract Objective: The study was aimed at investigating the hypoglycemic, antioxidant and Hepatoprotective effects of Chrysophyllum albidum in diabetes induced male Wistar rats. Methods: Ethanol root bark extract was administered to thirty rats of six groups A, B, C, D, E and F of five rats each, weighing between 150-170g. Diabetes was induced in Groups B, C, D, E and F using a single intraperitoneal injection of 140mg/kg of Alloxan after an overnight fast. Group A served as the normal…
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Summary: The present study was conducted to investigate the antifertility activity of the ethanol root bark extract of Chrysophyllum albidum on sperm parameter and hormonal levels in rats. Eighteen male rats were divided into three groups of six animals each. The first group (A) received distilled water and served as control. The second and third group (B & C) of animals were administered the ethanol root bark extract daily at 100mg/kg body weight and 200mg/kg decrease in the caudal epididymal…
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Objective: The aim of this study was to determine the effect of lime juice on the fetal parameters of Sprague-Dawley rats Materials and Methods: Forty adult female Sprague-Dawley (SD) rats were used. They were randomly divided into 2 groups (I and II) of 10 rats each. The estrous cycles of the rats were studied for the first 16 days to establish cyclicity. The rats were mated with male SD rats of proven fertility on the estrous day (heat period) of…
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ABSTRACT Potassium bromate (KBrO3) is classified as mutagenic and carcinogenic although used in food and cosmetics industries, and also found in drinking water as a by-product of disinfection. Industrial pollution of drinking water and its ability to cross the blood-brain barrier lead to the investigation of its effect on the cerebral cortex. Twenty adult Wistar rats with average weight of 200 g were divided into four groups designated as ‘A’ for the control group, and ‘B, C and D’ for…
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Abstract: Purpose: The ethanolic root bark of Chrysophyllum albidum were evaluated for their effect on antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation (malondialdehyde) activities in rats. Methods: Eighteen male Wister rats weighing 100-200g were divided into three groups of six animals each. Two treated groups received a daily dose of ethanolic root bark of Chrysophyllum albidum at 100mg/kg and 200mg/kg body weight respectively via gastric gavage, while equal volume of normal saline was administered to…
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ABSTRACT The purpose of the present study was to evaluate the effects of ethanolic leaf extract of Chrysophyllum albidum on hormones and sperm analysis of laboratory rats. Fifteen male rats weighing 230-250g were completely randomised into three groups: A-C. Animals in Group A (control) were orally administered with 0.5ml of distilled water once daily for 21 days while those in Groups B and C, received 500 and 1000mg/kg body weight of the extract respectively), and effect of the treatment on…
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ABSTRACT Objectives: Study was carried out to determine the incidence of male infertility in Medical Art Center, Maryland Ikeja Lagos, Western. Nigeria. Method: The specimens were collected and analyzed in the andrology laboratory. The standard method of masturbation after 3-5 days of prior abstinence from sex before sample collection was applied. The samples were examined for semen volume, morphology, sperm motility and count. Result: The semen samples of 263 (two hundred and sixty three) males attending infertility clinic, aged between…
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Abstract: It was therefore the aim of this study to find out whether long term consumption of cooked and uncooked beans (cowpea) diet has effects on some neurobehavioral parameters such as anxiety and fear using Swiss white mice as experimental animals, since cowpea contain serotonin and its precursor 5-Hydroxytryptophan which have neurobehavioral effects. Forty (40) Swiss mice were randomly assigned into four groups. Control (group A) were fed normal rodent chow, cooked beans (group B) received cooked beans diet (50%…
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Abstract The use of Mucunaflagellipes in recent time has been on the increase as a result of its speculated therapeutic effect mostly on the protein level of the body. And owing to the fact that there are no detailed reports on Mucunaflagellipes on its effect on neurobehavioral parameters, this work is therefore intended to investigate the possible effects of this herb on the exploratory behavior and body weight in Swiss white mice. Twenty (20) mice of mixed sex were randomly…
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Background: Telfairia occidentalis seed is a multipurpose plant with many attributes and considerable therapeutic potentials. Carbon Tetrachloride is one of the oldest and most widely used toxins for experimental induction of liver fibrosis in laboratory animals. The Liver is usually the organ to receive the effect of this chemical thereby causing hepatotoxicity, simply because of its method of metabolism, as well as carrying out the first pass effect by metabolizing endogenous and exogenous substances hence its consideration. Aim: The aim…
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ABSTRACT Manihot esculenta Crantz leaves have been used against many disorders, such as rheumatism, fever, headache, diarrhea, and loss of appetite. Cassava leaves reportedly also possess anti-hemorrhoid, anti-inflammatory, and antimicrobial activity. The aim is to investigate the effect of aqueous extract of Manihot esculenta and piroxicam co-administration for induced gastro-toxicity in male wistar rats and thus determine histo-morphologic changes in the stomach due to piroxicam-mediated toxicity. The leaves of Manihot esculenta leaves were collected and dried for two weeks at…
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ABSTRACT The aim of this present study is to investigate the effect of repeated administration of 5-Hydroxytryptophan diet (5-HTP) on learning and memory using CD-1 mice as experimental animals. Twenty male (20) mice were randomly assigned into two groups of ten mice each, namely; Control and 5-Hydroxytryptophan diet (15%w/w) groups. Feeding lasted for 28 days, during which there were daily measurements of food intake, water intake and body weight changes. Thereafter, the Morris water maze task was used to assess…
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Abstract Original Article Introduction Every individual needs a certain amount of body fat for energy, heat insulation, and shock absorption. However, excessive deposition of fat in the body, which is usually referred to as overweight or obesity, has been found to be medically deleterious to the body. Overweight specifically refers to an excess body weight compared to set standards, while obesity is to have an abnormally high proportion of total body fat.[1] Obesity is a medical condition in which excess…
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ABSTRACT Background: The morphology of an individual‘s external ear and its dimensions vary amongst persons to the point that the right and left ears differ. Aims: This study is aimed at establishing the anatomical variation in the auricular structure of the students of University of Port Harcourt, Nigeria. Methods: The study utilizes a total of 200 students, 101 male and 99 female subjects within the age range of 16-30 years. Total ear length and breadth of both ears were measured…
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Abstract Excess body fat deposition is known to be unhealthy. There have been several discourses on defined anthropometric indices for the assessment and a better prediction of obesity in pregnant women. This is because certain cut-off values relating to obesity in pregnant subjects are highly influenced by age, sex, ethnicity and trimesters of pregnancy. This study is aimed at investigating the use of two basic anthropometric indices to measure obesity and evaluate its prevalence in the different trimesters of pregnancy.…
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ABSTRACT Since prehistoric times, man has relied on herbal plants as source of medicine in curing various ailments. This study was carried out to assess the anti- anxiety-like effect of the ethanol extract of Wild fig (Ficus thonningii) in Swiss white (CD-1) mice. Thirty Swiss mice were randomly divided into three groups (1-3), n=10). Group 1 (control) was administered normal rat fed and saline, while group 2(low dose) and group 3(high dose) were administered 10mg/kg w/w and 20mg/kg w/w of…
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Abstract Ficus thonningii plant has been reported to be used for the treatment of various ailments, such as stomach ache, pain diarrhea, etc. Therefore, the present study was carried out to investigate its effect on exploratory/locomotor activities of the ethanol extract of the leaves of the plant. Exploration/locomotor behavior were assessed using the open field maze and the light/dark transition box tests. Animals were divided into three groups containing 10 mice each. Group A served as the control which was…
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The anxiolytic effect of the leaves of water lily was investigated using mice as experimental animals. Thirty (30) were mice randomly divided into group 1, 2 and 3. Before the neurobehavioral parameters were assessed, the LD50 and the phytochemical screening of the leaves of the plant were determined. The open field maze and the transition box apparatus were used to determine the level of fear and anxiety related behaviors in mice. In the open field arena, the grooming frequency was…
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ABSTRACT: The abuse of chemicals particularly psychoactive substances has been on the increase amongst the youth populace to the extent of becoming a front burner and top category public health concern in many developing nations of Africa, hence the aim of this study to evaluate the use of psychoactive substance and its risk factors among secondary school students in Port Harcourt LGA of Rivers State, so as to establish the prevalence rate of the use of the substances among the…
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Study Background: Toxoplasma gondii a protozoan and zoonotic infection can stimulate innate and adaptive immune responses. Aims and Objectives: This work was designed to determine relationship between parasitic infection of T. gondii, interleukin?2 (IL?2), tumor necrosis factor?alpha (TNF??), and Tryptophan and CD4+ count. Materials and Methods: A total of 150 individuals aged 21–73 years (male: 100 and female: 50) were recruited from Saki?West, Saki?East, and ATISBO local governments of Nigeria. Plasma TNF??, IL?2, Tryptophan, anti?hepatitis C virus (anti?HCV), hepatitis B…
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Background: Viral biomarkers in pulmonary tuberculosis (PTB) could be a primary or secondary viral infection to PTB which may depressed immunity or make the patient susceptible to the secondary infection. Aim and Objective: This work was, therefore, designed to determine frequency of anti?hepatitis C virus (HCV), hepatitis B envelope antigen (HBeAg), hepatitis B surface antigen (HBsAg), hepatitis B envelope antibody (HBeAb), and human immunodeficiency virus (HIV)?1 p24 in newly infected Mycobacterium PTB patients. Materials and Methods: Sixty newly infected Mycobacterium…
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Abstract Infectious agents and chemical substances can trigger the production and the release of cytokines. To determine the pattern of infectious agents in herbal homes patients with elevated TNF? (? 5.0 pg/ml) in Saki – West-Nigeria. The subjects include patients with elevated TNF? (? 5.0 pg/ml) in 15 herbal homes(n=23 ; aged 5-69 years; males – 13 ; females – 10) and patients with elevated TNF? in 3 major hospitals (n = 32; aged 6 -67years; males – 12 ;…
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An intellectual is a well educated person that could reason logically and understand the phenomena around him or her. The understanding through the Intellectual’s Education and Training enables him or her to be able to simulate and implement new strategies. A strategy is about generalship to have courses of action with such elements as product-market scope, goals and objectives, deployment of emphasis. Competitive advantage and distinctive competence, growth vector and synergy to achieve comprehensive organizational and national objective. …
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Abstract Background: Drepanocytosis (sickle cell anaemia) is a genetic disorder that causes stiff, rod-like sickle-shaped haemoglobin in red blood cells (RBCs) and consequently poses serious health complications. We investigated in vitro anti-sickling potential of a novel polyherbal formula (MPF). Methods: Sickling of RBCs induced with 2%sodium metabisulphite (MBS) was followed by treatment with MPF mixtures in different saline concentrations (7mg/ml, 9mg/ml, 14mg/ml and 28mg/ml). The red cell morphology was examined microscopically. Percentage sickling was quantified 30-minute interval at 370C for…
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ABSTRACT Infection with Hepatitis C Virus (HCV) is a public health problem. Worldwide, there are about 170 million people infected with HCV. HCV is transmitted through sex and use of contaminated sharp objects during tattooing or intravenous drug abuse. These routes make youth to be more vulnerable. Transfusion and mother to child transmissions are also documented modes. This study was carried out to determine sero-prevalence of hepatitis C virus infection among in school youth at Achievers University, Owo in southwest…
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ABSTRACT Background: The influences of tribes on coagulation profile have not been sufficiently investigated. However, Genetic factors contribute to the inter individual variation of blood coagulation protein levels (de Lange et al., 2001). This study was aimed to assess some coagulation profile on 420 subjects, age range 18-84years old, consisting of 60 subjects each from the different tribes (Igbo, Yoruba, Hausa, Ibibio, Ijaw, Urhobo and Efik) males and females all residing in Nnewi town, Anambra state Nigeria. Prothrombin Time (PT),…
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Social lifestyle plays a significant role in the transmission of human immunodeficiency virus (HIV). Hence, abstinence and faithfulness are important for preventing HIV transmission. This study aimed to determine the prevalence of HIV antibodies among Muslims in Osun state, Nigeria. A total of 1554 Muslims who attended mosques for worship and provided consent were recruited for this study. Relevant data were obtained using a pro forma designed for this purpose. Blood specimens were collected for HIV screening using Determine, Unigold,…
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Abstract Background: The lives of patients living with HIV/AIDs have improved in terms of longer life expectancy and quality. This has seen the emergence of complications of the disease and the drugs such as metabolic syndrome and re-emergence of tuberculosis. Co-infection with other viruses especially the hepatic viruses has also become a major source of concern. The aim of this research is to determine the incidence of hepatitis B and E among this group of patients. Methods and Findings: Blood…
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a b s t r a c t Aim: This studyisthefirstattemptconductedtodeterminetheco-infectionratesofHepatitisCvirus among peoplelivingwithHIV/AIDS(PLWHA)inourhospital.Thisisexpectedtoleadtoimprovementin treatment protocols. Background: Co-infection ofHepatitisCvirusinfectionandHIV(HumanImmuneDeficiencyVirus)infec- tion isnottobeunexpectedastheyshareroutesofinfection.Thedetectionofsuchpatientsisparticularly important asthetreatmentmayinvolvelifethreateningdruginteractions.Thiscouldresultinshorter life expectancyofthepatients. Materials andMethods: This isaprospectivestudy.Atotalof280subjectslivingwithHIV/AIDSwere recruited intothisstudy.Seraoftheparticipantsweresubjectedtoanti-HCVantibody(IgG)screening using thirdgenerationELISAkitfromDIA.PRO,Italy.TheprevalenceofHCVwasdeterminedandbar charts andtableswereutilisedtodepicttheprevalenceratesofvariousgroups. Results: Sixty five(23.2%)oftheparticipantswerefoundtobeco-infected.Noassociationwasestablished between age,sex,partnersstatus,previoustransfusion,andnumberofpartners. Conclusion: The prevalenceof23.2%forHCVamongPLWHAreportedforthiscommunityisalarming. More focusshouldbedirectedonmanagementofHCVcomponentofcoinfectionthanitisdonenow. Further studiesarerecommendedemployingmoleculartechniquestodeterminesubtypesofHCVthat may bepredominantandwhythisfigureofco-infectionissohighinthestudylocation.
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Summary This prospective study of parturients at a tertiary health institution in south-western Nigeria aims to identify the incidence, severity and obstetric factors predisposing to feto – maternal haemorrhage (FMH) in our population. The exclusion criteria were haemoglobinopathy and patient’s refusal of consent to participate in the study. The prepared slide was processed as in the acid elution test described by Kleihauer – Betke. The FMH was calculated using Mollison formula (Mollison 1972). Baseline data included maternal biodata, blood group,…
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Objective: HIV and HCV share routes of infection. Co-infection and its complications are therefore emerging as a major concern as patients on HAART have longer life expectancy. These complications have been well documented. It is necessary to determine in our environment what epidemiological factors are associated. This is expected to improve treatment protocols leading to increase quality of life and prolonged lifespan. Liver enzymes may be useful to monitor therapy. Materials and Methods: This is a prospective study. Seventy age…
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Hospital and community acquired infections, continue to be a threat to public health, causing morbidities and mortalities. This survey was carried out to determine the prevalence of Enterobacteriaceae in nosocomial and community acquired infections among adults in LAUTECH Teaching Hospital in Osogbo southwestern Nigeria. Two hundred and forty isolates from General Out Patient Department (GOPD) and two hundred and forty isolates from different wards (Surgical, Medical, Gyneacological, Pediatric, Burn Unit and Ear, Nose and Throat wards) of the hospital were…
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THE EFFECT OF HIGHLY ACTIVE ANTIRETROVIRAL TRHERAPHY ON CD4 COUNTS AND BODY WEIGHTS IN HIV/AIDS PATIENTS IN SOUTH WEST NIGERIA
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Abstract. Dengue fever is becoming one of the major public health problems in the world and its distribution has been premised on the migration of people from infected regions. This study was carried out to determine the prevalence of dengue virus IgG antibody among the patients with febrile conditions attending health facilities in Osogbo metropolis, Southwestern Nigeria. The blood samples collected between July and September, 2014 were tested for Plasmodium falciparum and the sera were subsequently subjected to Enzyme Linked
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Abstract Dengue virus is one of the causative agents of viral haemorrhagic fever, which is transmitted primarily through Aedes mosquitoes. Transmission of the virus through non-vector sources had been proven, although, it is the most common arthropod-borne viral infection in human. This study was carried out to determine the prevalence of Dengue Virus amongst voluntary blood donors in Osogbo, southwest Nigeria. Ninety one voluntary non-remunerated donors that satisfied donor suitability criteria in Nigeria; having been considered fit based on physical…
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Osogbo metropolis, with the aim of determining the degree of iron deficiency anaemia in the study population. One hundred confirmed anaemic and recently un-transfused patients with haemoglobin concentration level less than 8 g/dL were selected from two major hospitals in Osogbo. Participants were within aged 6 months – 65 years of both sexes. The parameters estimated were haematological indices using automation (Humancount machine). Serum iron and ferritin were also estimated using Atomic Absorption Spectrophotometry, blood film was made for every…
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Aims: A commercial rapid test kit for anti-Hepatitis C Virus (anti-HCV) detection was evaluated and compared for diagnosis of hepatitis C by detection of immunoglobulin G(IgG) antibodies against a third generation Enzyme Immunoassay(EIA) as gold standard. Methodology: A total of 560 patient serum samples were subjected to rapid screening with rapid test (immunochromatographic) strip supplied by Global Diagnostics and commercially prepared IgG capture EIA by DIA.PRO, Italy. Results: Of the 560 samples, anti HCV was detected in 31(5.54%) by ELISA,…
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The study was conducted to investigate the safety of combined extracts of Bryophyllum pinnatum (family: Crassulaceae) and Aloe barbadensis (family: Xanthorrhoeaceae) in rats. Forty rats were randomly selected and divided into four groups. Rats in groups I were administered with placebo as the control animals, while rats in groups II, III and IV were administered with aqueous extracts at 25mg/ml, 50mg/ml and 100mg/ml respectively for 28 days. Five milliliter (5ml) of blood was collected from either the ocular vein or…
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ABSTRACT PURPOSE: PMTCT interventions, especially initiation of Highly active antiretroviral therapy (HAART) has modified the natural history of HIV infection by reducing both peripartal and neonatal HIV infections, but the pattern of the immunologic responses of these pregnant women to HAART remains speculative. It is hoped from this study, to describe the pattern of immunologic response of naïve, HIV positive pregnant women on their first initiation on HAART. METHODS: This study described the pattern of CD4 changes observed in freshly…
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Abstract Background: Previous reports showed lack of consensus on the possible etiology of coronary artery disease (CAD) between HIV-treatment with highly active antiretroviral therapy (HAART) and HIV-infection in particular. The aim of this study was to find out correlations of HIV-treatment and HIV-infection with CAD risk. Method: One hundred and twenty (120) participants involving HIV-patients on treatment (n = 40), treatment-naïve (n = 40) and equal number of age- and sex-matched controls were enrolled. The total cholesterol, triglycerides and lipoprotein
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Abstract: Atherogenic cardiovascular risk assessment is important in the management of dyslipidaemia associated with antiretroviral therapy (ART). Generally, Castelli?s Risk Index (CRI), Atherogenic Index of Plasma (AIP) and Atherogenic coefficient (AC) are becoming useful indices as risk predictors for cardiovascular disease (CVD). We studied the importance of these indices in identifying at-risk HIV individuals receiving treatment. Eighty (80) HIV-patients comprising treatment (n=40) and treatment-naïve (n=40) groups with age- and sexmatched were enrolled. Traditional lipid parameters {Total cholesterol (TC), Triglycerol (TG),…
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Background: In the north central Nigeria, observed haemoglobin concentration is often used to determine the packed cell volume of patients, especially by many laboratories that cannot afford the cost of micro-haematocrit centrifuge. Aim: The study was carried out to determine the accuracy of 3-fold haemoglobin conversion to haematocrit level in anaemic conditions. Materials and Methods: The study was conducted on 580 symptomatic (febrile) patients and 810 subclinically anaemic subjects attending some selected private medical laboratories, hospitals and clinics in Kuje…
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ABSTRACT Compliance of 21 private medical laboratories in Osun State with ethical and other professional was assessed by the authors' pre and post inspection by the Medical Laboratory Science Council of Nigeria (MLSCN). Laboratory environment, personnel, equipment and adherence to Standard Operating Procedures (SOPs) were used as indicators and the results obtained were compared. Thirteen (62 %) was found to have conformed to environmental specifications before the MLSCN's inspection. This rose to 84% and 89% a month and 6 months…
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Aim: One third of HIV patients are co- infected with HCV. As HIV patients live longer this coinfection and its complications such as liver cirrhosis, hepatic carcinoma, metabolic syndrome are emerging as major manifestations of the disease that need to be dealt with promptly in order to avoid a reduction of the positive effects of highly active antiretroviral therapy (HAART) on HIV/AIDS introduced in 1996. Another system that could be affected by co-infection is the skeletal system. It has been…
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Introduction Medical laboratory science has been defined by the Medical Laboratory Science Council of Nigeria (MLSCN) Act 11 of 2003 as the practice involving the analysis of human or animal tissues, body fluids, excretions, production of biologicals, design and fabrication of equipment for the purpose of medical laboratory diagnosis, treatment and research1. Quality practices in medical laboratory service are of paramount importance in health care delivery
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The aim of this study was to determine the frequencies of ABO Blood groups and haemolysins (? and ß) in Osogbo metropolis. Seventeen thousands, nine hundred and thirty one subjects (Age?18) who consented to donating blood for transfusion and/or blood group determination were included in this study. About 5mls of blood were collected into plain bottles from each subject. Cells and sera grouping were subsequently carried out after clot retraction. Blood group O individuals have the highest frequency (53.6%) followed…
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ABSTRACT Background: Hepatitis C Virus (HCV) is an agent of Transfusion Transmissible Infection (TTI) which serves as a threat to blood safety and sufficiency of blood and blood products supply. Objectives: This study aimed at determining the distribution patterns of HCV among potential blood donors in a private Blood Bank in Osogbo, Nigeria. Materials and Methods: Over a period of 6 months, 290 consenting prospective blood donors were recruited for this study by convenient sampling technique. Pre-test counseling was done,…
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Abstract Background: HTLV type I/II is a blood borne infection that can be transmitted via blood transfusion. Objective: To determine the seroprevalence of human T – lymphotropic virus among blood donors in Osogbo, Nigeria. Methods: Diagnosis of Human T. Lymphotropic virus antigen was carried out on 372 serum samples among blood donors who visited the blood bank/transfusion unit of Ladoke Akintola University of Technology Teaching Hospital and Our Lady of Fatima Catholic Hospital, Osogbo between January and July 2008 using…
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My role as a blood transfusion coordinator in a rural new teaching hospital and distribution of ABO and RHO blood groups among patients attending Delta State University Teaching Hospital, Oghara during the period of July 2010 to March 2011
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BACKGROUND Drug-induced thrombocytopenia (DITP), which also includes thrombocytopenia induced by beverages, foods, and herbal remedies, is an important clinical problem for haematologists. Drug-induced thrombocytopenia is often misdiagnosed as immune thrombocytopenic purpura with resulting inappropriate treatment. Immune thrombocytopenic purpura (ITP) is a clinical disorder that leads to easy bruising (purpura), excessive bleeding or extravasation of blood from capillaries into skin and mucous membranes (petechiae). The bleeding tendency is due to decreased number of circulating platelets (thrombocytopenia). There is production of antibodies…
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ABSTRACT Background: There is continuous rise in haematology and haemato-oncology cases in Nigeria. Unfortunately, there is inadequate number of haematologists to care for these rising cases despite the high number of medical doctors being churned out by over twenty medical schools in Nigeria. Object: The aim of this study is to find out the preference rate of Haematology among medical students in a typical Nigerian medical school. Methodology: Questionnaires were used to collect data from medical students who met the
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Abstract Objective(s): The present study was designed to provide additional information on some hematological and biochemical changes associated with blood transfusion in sickle cell anemia (SCA) patients. Materials and methods: A total of 86 subjects (aged between 20 and 40 years) were randomly studied. Among these were 30 multi-transfused SCA (? 3 units of blood per year), 30 rarely transfused SCA (year) and 26 apparently healthy individuals. The blood samples collected in EDTA were used for packed cell volume, haemoglobin…
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ABSTRACT Background: The demand to study medicine in Nigeria is very high thereby putting lots of pressure to the University authorities because of inadequate space and provision to accommodate the large number of applicants. Objective: The aim of this study was to determine the factors motivating students and influencing their desire to study medicine and proffer solutions to reduce the population of applicants to medical schools. Methodology: Self-administered questionnaires were used to collect information from 311 medical students of Delta…
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ABSTRACT Background: Blood transfusion is a very essential part of medical practice. However, blood and blood component transfusions are associated with some adverse transfusion reactions. Some of these reactions can lead to loss of patients’ lives and hence defeating the essence of blood usage in saving lives. Objectives: This study aims to establish those factors promoting and increasing the susceptibility of patients for adverse transfusion reactions. Methodology: Two-year records (July 2014-June 2016) of our patients reported to have blood transfusion…
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Abstract Background: Blood and blood components transfusion is a very important component of medical practice and patients’care. However, this wonderful therapeutic tool is associated with some disadvantages namely adverse transfusion reactions which in some cases lead to fatal consequences defeating the essence of its usage. Objectives: This study aims to establish the modes of presentations (signs and symptoms) of blood transfusion reactions among recipients of blood in Delsuth, Oghara. Methodology: Records of our patients who were reported to have blood…
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Abstract Introduction: Haematological malignancies (HM) are malignant disorders involving the haemopoietic system. Oxidative stress has been implicated in the development and evolution of these disorders. To measure total antioxidant capacity (TAC) in patients with HM and to determine if any, the relationship between TAC and total lipid in these patients. Presentation of the case: This is a multicentre cross sectional study. Patients were sampled with self administered questionnaire that documented their biodata and the various types of haematological malignancies they…
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Abstract Background: Sickle cell disease is a chronic debilitating condition. Nigeria has the largest pool of the sickle cell gene in the world. Three to five million people are affected in Nigeria. Knowledge of the disease may help in reducing the national prevalence. Objective: To determine the level of awareness of sickle cell disease in a typical rural community of Delta State. Method: Structured researcher-administered questionnaires were used to collect information from residents of Akoku-Uno community of Delta state. Resuts:…
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Abstract Background: South-South geopolitical region of Nigeria is a region rich with oil exploration activities. The people in this region are exposed to petroleum products which is one of the factors associated with leukaemia. There are limited data on leukaemia among these people. This study sought to document the clinical and laboratory characteristics of patients with leukaemia from this region. Materials and methods: One hundred and sixty-three (163) case notes of patients from this region with the diagnosis of leukaemia…
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Summary Sickle cell anaemia (SCA) complications namely stroke, osteomyelitis, retinopathy, pulmonary embolism, renal failure, chronic leg ulcers, cholelithiasis, acute chest syndrome, avascular necrosis (AVN) of the head of femur, and others, affect virtually all systems of the body. The prevalence and pattern of the complications of this disorder in south-south Nigeria had not been documented. The objective of the study was to detect and analyze frequency of occurrence of the different types of complications seen in adult SCA patients in…
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ABSTRACT Background: Unlike Chronic Myeloid Leukemia (CML) whose genetic basis (the Philadelphia chromosome), has become a household name, that of Polycythaemia Vera and other non-leukemic myeloproliferative diseases has not equally received wide publicity. Aim: The aim of this paper is to review and highlight the role of JAK2 mutation in Polycythaemia Vera, Primary Myelofibrosis and Essential Thrombocythaemia. Methods: Literature on the subject was reviewed using manual library search, articles in journals, internet search and conference abstracts. Results: JAK2 mutation plays…
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IntrOduction Historically, the first case of sickle cell disease (SCD) was reported in 1910 by a Dental Surgeon who made blood films of one of his patients and demonstrated red blood cells having a "slender sickle shape' ,.1 The history of sickle cell anaemia is a very good reminder of the importance of supportive role of the laboratory to clinical diagnosis and research'". The observation that sickle cell trait may have a survival advantage against malaria was based on the…
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ABSTRACT Background: Disseminated intravascular coagulation is an acquired acute, subacute or chronic coagulation or thrombohaemorrhagic disorder characterized by formation of microthrombi, consumption of coagulation factors/platelets, activation of fibrinolytic system and haemorrhage. It occurs as a secondary complication to a variety of disorders and infectious diseases but its occurrence in tuberculosis is rare and has not been reported. Objective: The aims of this paper are to present a case of Disseminated Intravascular Coagulation complicated by Acute Renal Failure in a patient…
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Summary Chronic Myelogenous Leukemia (CML) is a myeloproliferative disorder. characterized by the presence of Philadelphia chromosome and affects a good number of Africans and African-American population. The aim of this review is to highlight the aetiophysiology, clinical/laboratory characteristics and treatment options, especially the new and emerging treatment modalities of CML. The review was sourced mainly from internet (pubmed). Relevant Oncology journals and textbooks of haematology were also consulted. There are reported cases of relapse/resistance to imatinib which is the current…
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Abstract Background: Churg Strauss syndrome is a medical COIId-tionof unknoVin aetiology characterized by as/hma, eosinophilia and finally vasculitis involving small vessels in thelimbs and nasal sinuses aoo the lungs. The purpose of this Tevie is to highlight the natural history of this condifon, the pathogenesis, clinical features and lteatmenl modalities available and the prognosis. Methods: Literature on the subJect Vias reviewed using manuallibrary search. articles injoumals, internet search andconference abstracts. . Result Churg Strauss syndrome has been reported to be…
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ABSTRACT Background/Objective: In a rapidly developing world where conflicts are inevitable and accidents and other forms of trauma are constantly encountered there is an increased need for blood transfusion to keep victims ofthese events alive. As the need for blood increases, there is a corresponding decrease in the amount of blood available for transfusion due to increased demand and a falling donor pool. In addition, there are people who due to religious reasons abhor blood transfusion. The emergence ofthe HIV…
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ABSTRACT Background: Acquired Immunodeficiency Syndrome (AIDS) pandemic has become a major global public health problem, the brunt of which is largely borne by communities in Sub-Saharan Africa. Objectives: The aim ofthis review is to highlight and bring to the fore the peripheral blood and bone marrow changes ofHIV and AIDS because many Hlv-infected persons may present with these changes as more patients with this disease survive longer because oftherapy. Methods: The review was sourced mainly by pubmed search using the…
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AdescriPtive retrospctive study of the pattern of children admitted between ugust 2002 and January 2005 inclusive to the department of Paediatrics of Central Hospital Ughelli, an urban community in the oil rich Niger-Delta region of Nigeria was done. Children between 2 months and 3 years constituted 64.1% of the total admissions and 79% of those with severe anaemia that required transfusion. The neonatal admissions was just 0.3% of the total admissions but the neonatal transfusion was O.7% of the total…
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ABSTRACT Background: The higher prevalence of blood group 0 places more demand on it when compared to other blood groups in developing countries. Group 0 blood is usually abused in hospitals with the erroneous belief that individuals with blood group 0 are universal donors. Haemolysins are IgG antibodies seen particularly in blood group 0 subjects and their demonstration in vitro helps detect dangerous blood group 0 donors whenever such blood is to be given to non-O individuals. Objective: The aims…
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ABSTRACT Background: Idiopathic Myelofibrosis is a non-leukemic myeloproliferative disorder characterized by generalized fibrosis of the bone marrow in association with extramedullary haematopoiesis mainly in the spleen and liver. Prominent among its laboratory features are the presence of tear drop red blood cells (dacryocytes) and immature red blood and white cells (leukoerythroblasts) in the peripheral blood film. Aim: The objectives of this paper are to present a case of Idiopathic Myelofibrosis without the usual peripheral blood film picture and also to…
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Abstract Background: Petroleum exploration has been associated with diverse health problems in many parts of the world. There are reports of increased incidences ofhaematological malignancies in the areas where petroleum exploration is taking place. Petroleum exploration and exploitation has been ongoing in many countries and people living in these areas have borne the brunt ofthe environmental and health devastation taking place and efforts are not made to educate these people ofthe hazards they are encountering Objective: The aim of this…
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SUMMARY Objective: To determine the incidence and soclodemographic factors associated with various adult leukaemia subtypes in a tertiary hospital in, Nigeria. Patients and Methods: A total of 190 patients with a diagnosis of leukaemia seen OVf:T a 12-year period (1990.2002) at the University of Benin Teaching Hospital, Nigeria were studied. They were analyzed in the context of gender, marital status, geographical abode. educational and occupational status, Results: There were 70 males and 120 females with a male-to-female ratio of 1:1.7.
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SUMMARY The case of a 54-year eld woman who never knew she had sickle cell anaemia until she presented with a two week history of weakness, fever.loss of appetite. nausea, easy fatiquability and upper abdominal pains is presented. She was a known hypertensive and peptic ulcer disease prior to presentation. Her Peripheral blood film and haemglobin electrophoresis confirmed diagnosis of sickle cell anaemia. It is highlighted that while diagnosis commonly occurs in childhood, symptomatology of the disease can occur in
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Background: The blood of a pregnant woman is quite unique with a lot of interesting challenges. In non-pregnant women, certain alterations in haematopoeitic systems call for therapeutic interventions. In the state of pregnancy, however, some of such changes are regarded harmless because of reversal to non-pregnant values after delivery. On the other hand, management of some bloodrelated pathologies in pregnancy puts the healthcare provider at his/her wits end because of the consideration of possible effect(s) of any treatment modality on…
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Background: Blood saves lives only when the blood itself is safe. The safety of blood depends on the quality of its donor and these donors can be categorized into commercial, replacement and voluntary blood donors. Aim and Objective: The aim of this study was to determine the socio-demographic factors and categories of blood donors in Warri, Southern Nigeria. Materials and Methods:A Semi-structured self-administered questionnaire was used to collect all necessary information from blood donors. Results: A total of 500 blood…
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Background: The study was conceived to assess the seroprevalence of human immunodeficiency virus among blood donors living in Warri South South region of Nigeria. The importance ofthis study is to highlight the prevalence of HIV in different age groups of blood donors. Methods: This was a descriptive analysis of the records ofa total of3518 blood donors for the year 2002 to ascertain the age distribution and the sero-positivity for the human immunodeficiency virus. Descriptive statistics was used to present the…
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Abstract Background: The increased need of safe blood and blood products and their unavailability in hospitals remain a formidable challenge faced by healthcare providers in developing countries such as Nigeria. Airn:To determine the level of awareness of blood donation among tertiary institution undergraduates in an urban setting of Southern Nigeria. Methodology: Semi-structured questionnaire was used to collect information from undergraduates of the University of Benin and Delta State University both in southern Nigeria. Data analysis was done using SPSS software…
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Abstract Background: Carbon monoxide is a tastelessvodourless, colourless, non-irritating, and poisonous gas produced by incomplete combustion of organic materials. It is particularly dangerous as it cannot be detected by man's natural sense organs. There is hardly a month without one or two newspaper reports of death attributed to carbon monoxide poisoning. Objective: To determine the students' knowledge about carbon monoxide poisoning, and their ability to identify victims suspected of suffering from carbon monoxide poisoning. Methodology: A descriptive, cross-sectional study was…
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Abstract Background: Human Immunodeficiency Virus/HfV) and Hepatitis B Virus(HBV) infections are global viral diseases with various seroprevalence rates in different parts of the world. They share similar modes of transmission and are very important in Transfusion Medicine. Aim/Objective: To determine the level of awareness and practice of HIV and Hepatitis B virus screening among Niger-Delta residents. Methodology: Semi-structured questionnaire was used to collect information from residents in Benin and Warri towns of southern Nigeria. Results: A total of 396 people…
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Summary Solitary plasmacytomas are defined as proliferation of monoclonal plasma cells without evidence of significant bone-marrow plasma-cell infiltration. They are classified according to location into solitary plasmacytoma of bone if they occur in bone, and extramedullary plasmacytoma if they arise in soft tissues. They are more frequent in males than females and have a peak incidence in the fifth and sixth decade of life. Solitary plasmacytoma accounts for about 5% of plasma cell tumours. More than 80% of extramedullary plasmacytoma…
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Abstract Background: Pre-marital screening programme is aimed at reducing the incidence of hereditary and sexually transmitted diseases in the society. The study was carried out to determine the types of tests done by churches in Oredo LOA, Benin City. Methods: A descriptive cross-sectional study was carried out among all the 140 churches in Ihogbe and Ogbe quarters in Oredo LOA of Benin-City, Nigeria. Result: Out of a total of 140 churches studied through their church leaders, all of them requested…
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ABSTRACT Leucocytosis, marked increase in the number of white blood cells (WBC) is a known physiological response to trauma. In recent times, several studies have asserted the absence of this response in Africans. In view of this, current study investigated the existence of, and prognostic implications of post-traumatic leucocytosis amongst adult Nigerians with acute musculoskeletal (MSK) trauma. Two hundred and twenty three (223) adult male and females (MSK traumatized) and fifty apparently healthy volunteers (adults) were ethically recruited from the…
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Background: Moringa oleifera, otherwise referred to as a miracle tree, has been used in the treatment of numerous diseases. Moringa has been the subject of intensive scientific research; however, there has been scant information on its sub?acute effect on the kidneys. This work was done to investigate the histological and biochemical effect of M. oleifera on the liver and lungs of adult Wistar rats. Twenty?eight adult healthy rats were used for this study. The rats were divided into four groups…
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Background: Moringa oleifera, otherwise referred to as a miracle tree, has been used in the treatment of numerous diseases. Moringa has been the subject of intensive scientific research; however, there has been scant information on its sub?acute effect on the kidneys. This work was done to investigate the histological and biochemical effect of M. oleifera on the liver and lungs of adult Wistar rats. Twenty?eight adult healthy rats were used for this study. The rats were divided into four groups…
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Background: Moringa oleifera, otherwise referred to as a miracle tree, has been used in the treatment of numerous diseases. Moringa has been the subject of intensive scientific research; however, there has been scant information on its sub?acute effect on the kidneys. This work was done to investigate the histological and biochemical effect of M. oleifera on the liver and lungs of adult Wistar rats. Twenty?eight adult healthy rats were used for this study. The rats were divided into four groups…
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ABSTRACT Parasitosis is a major health problem in Nigeria with 50% prevalence among urban dwellers and 68% prevalence among rural population. Serum IgE differs with allergy and chronicity of infection but information on IgE levels in humans with different classes of parasites is scarce. Stool and blood specimens collected from apparently healthy, asymptomatic, school children were examined for ova, cysts and larvae of intestinal parasites and for trophozoites of Plasmodium species respectively. Serum IgE level was measured by ELISA method…
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Background: Vitamin D deficiency (VDD) continues to be associated with schizophrenia, but there is the dearth of information on the relationship between the severity of schizophrenia and plasma levels of vitamin D. This study, therefore, determined the plasma levels of vitamin D in different severity groups of schizophrenia. Materials and methods: Plasma level of vitamin D was determined in 60 patients with schizophrenia and 30 apparently healthy individuals who served as controls. Patients with schizophrenia were classified into mildly ill,…
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ABSTRACT Background: Due to the clinical benefits of metformin, its associated side effects such as vitamin B12 deficiency are usually overlooked and rarely investigated. Objective: This study was carried out to determine the serum level of vitamin B12 in Nigerian patients with type 2 diabetes mellitus (T2DM) on metformin. Methods: Serum vitamin B12 level was determined using high performance liquid chromatography (HPLC) in 81 T2DM patients who have been on metformin for 5 years or more. Vitamin B12 deficiency was…
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Abstract Background: Mycobacterium tuberculosis and human immunodeficiency virus (HIV) are known to cause abnormal thyroid function. There is little information on whether HIV infection aggravates alteration of thyroid function in patients with MDRTB. Objectives: This study was carried out to determine if HIV co-infection alters serum levels of thyroid hormones (T3, T4) and thyroid stimulating hormone (TSH) in patients with MDR-TB patients and to find out the frequency of subclinical thyroid dysfunction before the commencement of MDR-TB therapy. Methods: This…
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Abstract Objective: This study assessed the diagnostic performance and prognostic properties of C-reactive protein (CRP), copeptin and cortisol in individuals with sickle cell anaemia (SCA). Design: Prospective case-control study Methods: Sixty consecutive SCA subjects (18–40 years) comprising 30 subjects in the steady state and 30 subjects in vasoocclusive crisis (VOC) were recruited into this study. Thirty (30) apparently healthy individuals with HbAA genotype served as controls. ELISA was used for the determination of serum levels of copeptin, CRP and cortisol.…
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ABSTRACT Aim: To provide information on the usefulness of salivary immunoglobulin classes in the diagnosis of periodontitis. Materials and methods: About 5 ml of unstimulated saliva was collected from 25 newly diagnosed subjects with periodontitis and 21 sex/age-matched apparently healthy individuals into plain sample bottles. The samples were collected between 9 am and 11 am at least, 1 hour after eating or washing of mouth and levels of salivary immunoglobulin classes (IgA, IgG, IgE and IgM) were determined using enzyme-linked…
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Summary: It is well known that individuals with SCA undergo constant physiological stress even, in steady state. However, there is little information on the relationship between the severity of sickle cell anaemia (SCA) and serum levels of biomarkers of stress. This study therefore determined the serum levels of copeptin, cortisol and CRP in adults with SCA in different severity groups. Sixty adults with sickle cell anaemia in steady state (27.1±6.3 years) and in vaso-occlusive crisis (24.9±4.9 years) were recruited into…
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ABSTRACT Background: Abnormal lipid homeostasis has been reported in sickle cell anaemia (SCA) as well as in other haematological disorders. However, there is little information on the lipid profile of SCA subjects in vaso-occlusive crisis (VOC). This study determined the lipid profile of adult SCA subjects in VOC and in steady state (SSCA). Materials and Methods: Fifty-eight (58) adults with HbSS (30 in steady state and 28 in vaso-occlusive crisis) and 24 age-matched healthy individuals with HbAA genotype were recruited…
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Abstract: Background: Metabolic Syndrome (MS) increases the risk of developing type-2 diabetes (DM2) and cardiovascular diseases (CVD) and it is thought to be prevalent in Nigeria. This study aims at determining the prevalence of MS and its component risk factors among apparently healthy traders in a local market in Ibadan, Nigeria. Methods: 534 apparently healthy traders from a local market in Bodija, Ibadan, Nigeria aged (18–105) years with neither DM2 nor CVD were participants of a cohort study on risk
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ABSTRACT The incorporation of nutritional screening and comprehensive assessments of oxidative stress is increasingly recognised as imperative in the development of standards for quality care in oncology. This study evaluated the levels of nitric oxide (NO), some essential trace metals (Zn, Cu, Fe, and Se), superoxide dismutase (SOD) activity and malondialdehyde (MDA) in twenty five (25) patients with acute leukaemia and 25 apparently healthy controls. The mean levels of plasma Zinc (Zn), Iron (Fe) and Selenium (Se) were not significantly…
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Aim: To provide information on the susceptibility of cigarette smokers to oral diseases. This was achieved by assessing the degree of salivary oxidative stress markers in smokers with or without periodontitis. We measured salivary concentrations of malondialdehyde (MDA) and hydrogen peroxide (H2O2), myeloperoxidase (MPx) activity, enzymatic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and glutathione peroxidase (GPx activities) and reduced glutathione (GSH) concentration. Materials and Methods: About 5 ml of unstimulated saliva was collected into plain bottles from…
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Background: The effect of Human Immunodeficiency Virus (HIV) on the immune system is well documented however; its impact on the nutritional and immunological qualities of the breast milk is scarce. Aim: Levels of some essential trace metals, albumin and antioxidant status in the plasma and breast milk of Nigerian HIV?infected lactating mothers were determined. Materials and Methods: Essential trace metals and total antioxidant potential were measured using spectrophotometric method while albumin was measured using single radial immunodiffusion technique. Results: Only…
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Abstract: Background: Insulin resistance and metabolic alteration continue to be essential features of major mental health disorders (MMHD) with poorly understood and multifaceted mechanisms. This study was carried out to provide information on insulin resistance, beta-cell function, metabolic clearance rate of glucose and their possible interplay with duration of antipsychotic use in patients with major mental health disorders.
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Abstract Background: Sickle cell disease (SCD) is an inherited chronic hematological disorder, with inflammatory responses arising from different pathways. Information is scarce about the levels of acute?phase reactants and essentials trace elements in HbSS Nigerian children. Understanding of these will further elucidate the pathophysiology of SCD, which may assist in the proper management of this condition in the pediatric population. Aim: To measure the levels of acute?phase reactants (C?reactive protein [CRP], C1q, C4, ferritin and transferrin), trace elements (Fe, Zn,…
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Abstract Background: Reports have clearly indicated the role of oxidative stress in the pathogenesis of organophosphate pesticides (Op) toxicity. However, there is dearth of information on which group of the farm workers is more at risk of Op?induced oxidative stress. Aim: This study determined serum levels of malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), myeloperoxidase (MPO), nitric oxide (NO), and serum activity of acetylcholinesterase (AChE) in farm workers exposed to Op. Subjects and Methods: A total of…
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Objective: This study evaluated the effects of a 12-month dietary modification on indices of inflammation and pro-thrombosis in adults with metabolic syndrome (MS). Materials and methods: This longitudinal study involved 252 adults with MS recruited from the Bodija market, Ibadan and its environs. Participants were placed on 20%, 30% and 50% calories obtained from protein, total fat and carbohydrate respectively and were followed up monthly for 12 months. Anthropometry and blood pressure were measured using standard methods. Fasting plasma glucose…
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Background: Suscep???? bility of sickle cell disease subjects to various infec???? ous agents is on the increase, but informa???? on rela???? ng SCD to allergic condi???? on is scarce. Hence, assessment of immunoglobulin status in SCD children may provide useful informa???? on to improve management of SCD children. Objec???? ves: To determine the levels of immunoglobulin classes (IgG, IgA, IgM, and IgE) in Nigerian HbSS children below 5 years of age compared with sex- and age-matched HbAA children. Materials and…
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ABSTRACT Acute leukaemia are usually rapidly progressive with death often occurring in a few weeks to a few months in untreated patients as a result of abnormal hematopoietic function as well as impaired immune response. The risk of relapse which remains in 20% of patients in remission calls for more research on acute leukaemia. This study therefore, evaluated the plasma levels of nitric oxide (NO), interleukin-4 (IL-4), interferon-gamma (IFN-?) and immunoglobulin classes (IgA, IgG, IgM, IgE) in twenty-five (25) patients…
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Metabolic syndrome (MS) amplifies hypertension (HTN) associated with increased risk of cardiovascular disease (CVD). MS components and other CVD risk measures were investigated in different stages of hypertension. 534 apparently healthy Nigerian traders aged 18–105 years were participants of a cohort study.The International Diabetes Federation (2005) and the National High Blood Pressure Education Program Coordinating Committee criteria were used for MS and HTN classifications, respectively. Anthropometric indices were obtained by standard methods. Levels of fasting plasma glucose (FPG), total cholesterol…
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This study evaluated the effect of vitamins with antioxidant activity on the effect of Dichlorvos (2, 2-dichlorovinyl dimethyl phosphate), an organophosphorus compound used in pest control on mammalian organs. Literature is scanty on the histopathological effects of inhalationally administered dichlorvos, especially of the formulations used in Nigeria. The objective of the study is to evaluate these effects on vital organs, with a view to proffering solutions to ameliorate the effects. Fifty Wistar male rats were divided into 10 groups of…
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Abstract B A C K G R O U N D The prevalence of helminth infection, which is known to affect nutritional status of the host, varies with age. The complex interplay between ages, nutrient requirements, and infection necessitated the need to recommend micronutrient supplementation during helminth infection among different age groups. O B J E C T I V E The aim of this study was to determine the pattern of alteration in selected micronutrients in pregnant women and…
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ABSTRACT Background: There is little information on the possible impact of drugs used in the treatment of multi-drug resistant tuberculosis (MDR-TB) on glycaemic levels. This study therefore assessed changes in glycated haemoglobin levels in patients with MDR-TB. Materials and Methods: This longitudinal study involved 21 MDR-TB patients who were followed up for 6 months. Glycated haemoglobin (HbA1c) level of each patient was determined before the commencement of MDR-TB drug regimen and at 2, 4 and 6 months post treatment as…
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Abstract Presently, there is the dearth of information on the impact of human immunodeficiency virus (HIV) infection on haematological parameters in patients with multidrug resistant tuberculosis (MDR-TB). Therefore, this study was carried out to determine the levels of selected haematological parameters in MDR-TB patients with or without HIV co-infection before the commencement of MDR-TB therapy. Complete blood count and erythrocyte sedimentation rate (ESR) were determined using an automated haematology analyzer and Westergreen method respectively in 115 patients with MDR-TB. Statistical…
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GLYCAEMIC RESPONSEAND INSULINE INDEX IN APPERENTLY HEALTHY MALE ADULTSFOLLOWING INGESTION OF SOME NIGERIAN MEALS 2018/2019
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ABSTRACT Experimental studies have shown numerous health disorders associated with occupational exposure to organophosphate pesticides but evidence of impaired immune functions by pesticides in humans is scarce. This study determined complete blood count (CBC), serum immunoglobulin classes (IgE, IgA, IgM, IgG),acetylcholinesterase (AChE) activity and skin sensitivity prick test to common environmental allergens in 60 farm workers (30 pesticide applicators and 30 farmers) exposed to organophosphate (OP) pesticides compared with30 apparently healthy, non-exposed workers. Serum AChE activity, mean PCV level, total…
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Background An understanding of the interplay between mental illnesses and metabolic disorders is crucial. At present, in Nigeria, studies on coexistence of these conditions are scarce. Therefore, this study was carried out to determine the prevalence of obesity, metabolically healthy obesity (MHO) and metabolic syndrome (MS) in adults with major mental illnesses. Materials and methods One hundred and twenty four patients with schizophrenia, depression and bipolar disorder were recruited into this cross-sectional study. Blood pressure and anthropometric indices were obtained…
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Aim: To assess the prevalent components of metabolic syndrome (MSC) and their related determinants of lipid metabolism in the Nigerian for early diagnosis, prevention Original Research Article International Journal of TROPICAL DISEASE & Health, 4(7): 740-752, 2014 741 and management of the metabolic syndrome (MS) and its associated diseases. Study Design: Cohort study. Place and Duration of Study: Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan between March and August 2010. Methodology: 534 apparently healthy Nigerian traders…
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Abstract B A C K G R O U N D Helminth infection is an important health challenge. Because of modulation of the immune response toward T-helper 2 (Th2) cells, the immunologic interplay that manifest during the coexistence of helminth infection with other conditions is still poorly understood. O B J E C T I V E This study determined the pattern of alteration in selected cytokines and immunoglobulin E (IgE) in pregnant women, preschool aged children, and school-aged children…
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ABSTRACT Undernourishment in HIV infected individuals exacerbates immunosuppression, acceleration of HIV replication and CD4 + T cell depletion. The production of human milk (lactogenesis) is dependent on factors in the blood therefore deranged blood parameters in HIV patients are expected to reflect in the components of breast milk. Study on effects of HIV infection on nutritional components of breast milk and plasma is scarce. This study assessed the impact which HIV infection might have on the nutritional quality of human…
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ABSTRACT Despite the high mortality and morbidity associated with hyperglycemic emergencies (HEs), reliable biological markers that could predict the severity and prognosis are largely unavailable. This study therefore, assessed the performance of copeptin in predicting the severity and prognosis of HEs. Sixty patients with HEs [27 with diabetes ketoacidosis (DKA) and 33 with hyperglycemic hyperosmolar state (HHS)] were recruited into this cross-sectional study. Serum copeptin was determined using ELISA. Glasgow Coma Scale (GCS) was used to grade the severity of
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ABSTRACT Dichlorvos is an organophosphate insecticide used indiscriminately in Nigeria in various insecticide formulations due to its cheap production, accessibility, efficacy and affordability. Reactive oxygen species formation has been implicated in the mechanism of dichlorvos toxicity. Reports on antioxidant-prooxidant status in human users of dichlorvos are scarce and the few available reports are conflicting. 35 wistar rats were divided into 7 groups of 5 rats per group as follows; unexposed group, six groups exposed to dichlorvos for 1week, 2weeks, 3weeks,…
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Abstract The interaction between vitamin D deficiency (VDD) and dysfunction of both the kidney and liver is still poorly understood in different health states of SCA. This study determined serum levels of vitamin D and indices of liver and renal function in adult sickle cell anaemia subjects. Sixty subjects with sickle cell anaemia (30 in steady state [SSCA] and 30 in vaso-occlusive crisis [VOC]) and 30 apparently healthy individuals with HbAA genotype were recruited into this study. Standard methods were…
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Abstract Prolonged exposure to organophosphate pesticides (Op) has been associated with various diseases. There is little information on which group of exposed farm workers that is more affected. This study therefore evaluated indices of hepatic and renal function in pesticide applicators and farmers exposed to organophosphate pesticides. Thirty (30) pesticide applicators (PA), 30 farmers exposed to Op and 30 control subjects were recruited into this study. Serum activity of acetyl cholinesterase (AChE) was determined using HPLC while total bilirubin (TBIL),…
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